Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin can explain hyperglucagonemia in type-2 diabetes.

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Autores principales:	Muhmmad Omar-Hmeadi, Per-Eric Lund, Nikhil R. Gandasi, Anders Tengholm, Sebastian Barg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e632b127eee5439face77166a636f601
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spelling	oai:doaj.org-article:e632b127eee5439face77166a636f6012021-12-02T16:56:33ZParacrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes10.1038/s41467-020-15717-82041-1723https://doaj.org/article/e632b127eee5439face77166a636f6012020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15717-8https://doaj.org/toc/2041-1723Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin can explain hyperglucagonemia in type-2 diabetes.Muhmmad Omar-HmeadiPer-Eric LundNikhil R. GandasiAnders TengholmSebastian BargNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muhmmad Omar-Hmeadi Per-Eric Lund Nikhil R. Gandasi Anders Tengholm Sebastian Barg Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
description	Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin can explain hyperglucagonemia in type-2 diabetes.
format	article
author	Muhmmad Omar-Hmeadi Per-Eric Lund Nikhil R. Gandasi Anders Tengholm Sebastian Barg
author_facet	Muhmmad Omar-Hmeadi Per-Eric Lund Nikhil R. Gandasi Anders Tengholm Sebastian Barg
author_sort	Muhmmad Omar-Hmeadi
title	Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
title_short	Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
title_full	Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
title_fullStr	Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
title_full_unstemmed	Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
title_sort	paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e632b127eee5439face77166a636f601
work_keys_str_mv	AT muhmmadomarhmeadi paracrinecontrolofacellglucagonexocytosisiscompromisedinhumantype2diabetes AT perericlund paracrinecontrolofacellglucagonexocytosisiscompromisedinhumantype2diabetes AT nikhilrgandasi paracrinecontrolofacellglucagonexocytosisiscompromisedinhumantype2diabetes AT anderstengholm paracrinecontrolofacellglucagonexocytosisiscompromisedinhumantype2diabetes AT sebastianbarg paracrinecontrolofacellglucagonexocytosisiscompromisedinhumantype2diabetes
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

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