EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer
Although the TMPRSS2-ERG gene fusion is the most common alteration in human prostate cancer, its involvement in disease progression remains unclear. Here, the authors demonstrate that ERG is methylated by Enhancer of zest homolog 2 leading to enhanced transcriptional and oncogenic activity.
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Nature Portfolio
2021
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oai:doaj.org-article:e634d5688e6b4dc7aff08bbd1aa3f1c92021-12-02T16:15:08ZEZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer10.1038/s41467-021-24380-62041-1723https://doaj.org/article/e634d5688e6b4dc7aff08bbd1aa3f1c92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24380-6https://doaj.org/toc/2041-1723Although the TMPRSS2-ERG gene fusion is the most common alteration in human prostate cancer, its involvement in disease progression remains unclear. Here, the authors demonstrate that ERG is methylated by Enhancer of zest homolog 2 leading to enhanced transcriptional and oncogenic activity.Marita ZomaLaura CurtiDheeraj ShindeDomenico AlbinoAbhishek MitraJacopo SgrignaniSarah N. MapelliGiada SandriniGianluca CivenniJessica MerullaGiovanna ChiorinoPaolo KunderfrancoAlessia CacciatoreAleksandra KokanovicAndrea RinaldiAndrea CavalliCarlo V. CatapanoGiuseppina M. CarboneNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Marita Zoma Laura Curti Dheeraj Shinde Domenico Albino Abhishek Mitra Jacopo Sgrignani Sarah N. Mapelli Giada Sandrini Gianluca Civenni Jessica Merulla Giovanna Chiorino Paolo Kunderfranco Alessia Cacciatore Aleksandra Kokanovic Andrea Rinaldi Andrea Cavalli Carlo V. Catapano Giuseppina M. Carbone EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer |
| description |
Although the TMPRSS2-ERG gene fusion is the most common alteration in human prostate cancer, its involvement in disease progression remains unclear. Here, the authors demonstrate that ERG is methylated by Enhancer of zest homolog 2 leading to enhanced transcriptional and oncogenic activity. |
| format |
article |
| author |
Marita Zoma Laura Curti Dheeraj Shinde Domenico Albino Abhishek Mitra Jacopo Sgrignani Sarah N. Mapelli Giada Sandrini Gianluca Civenni Jessica Merulla Giovanna Chiorino Paolo Kunderfranco Alessia Cacciatore Aleksandra Kokanovic Andrea Rinaldi Andrea Cavalli Carlo V. Catapano Giuseppina M. Carbone |
| author_facet |
Marita Zoma Laura Curti Dheeraj Shinde Domenico Albino Abhishek Mitra Jacopo Sgrignani Sarah N. Mapelli Giada Sandrini Gianluca Civenni Jessica Merulla Giovanna Chiorino Paolo Kunderfranco Alessia Cacciatore Aleksandra Kokanovic Andrea Rinaldi Andrea Cavalli Carlo V. Catapano Giuseppina M. Carbone |
| author_sort |
Marita Zoma |
| title |
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer |
| title_short |
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer |
| title_full |
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer |
| title_fullStr |
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer |
| title_full_unstemmed |
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer |
| title_sort |
ezh2-induced lysine k362 methylation enhances tmprss2-erg oncogenic activity in prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e634d5688e6b4dc7aff08bbd1aa3f1c9 |
| work_keys_str_mv |
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| _version_ |
1718384324545347584 |