Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis

A numerical simulation of a pulsed floating electrode dielectric barrier discharge (FE-DBD) at atmospheric pressure, used for melanoma cancer cell therapy, is performed using a plasma model in COMSOL Multiphysics software. Distributions of electron density, space charge, and electric field are prese...

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Auteurs principaux:	Samira Elaissi, Kamel Charrada
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	cold atmospheric plasma floating electrode cancer therapy atmospheric pressure pulse discharge simulation Engineering (General). Civil engineering (General) TA1-2040
Accès en ligne:	https://doaj.org/article/e637948ab01a4e95b6971ba9f3ab97af
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spelling	oai:doaj.org-article:e637948ab01a4e95b6971ba9f3ab97af2021-11-25T17:16:53ZSimulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis10.3390/coatings111114052079-6412https://doaj.org/article/e637948ab01a4e95b6971ba9f3ab97af2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6412/11/11/1405https://doaj.org/toc/2079-6412A numerical simulation of a pulsed floating electrode dielectric barrier discharge (FE-DBD) at atmospheric pressure, used for melanoma cancer cell therapy, is performed using a plasma model in COMSOL Multiphysics software. Distributions of electron density, space charge, and electric field are presented at different instants of the pulsed argon discharge. Significant results related to the characteristics of the plasma device used, the inter-electrodes distance, and the power supply are obtained to improve the efficiency of FE-DBD apparatus for melanoma cancer cell treatment. The FE-DBD presents a higher sensitivity to short pulse durations, related to the accumulated charge over the dielectric barrier around the powered electrode. At higher applied voltage, more energy is injected into the discharge channel and an increase in electron density and electric consumed power is noted. Anticancer activity provided by the FE-DBD plasma is improved using a small interelectrode distance with a high electron emission coefficient and a high dielectric constant with a small dielectric thickness, allowing higher electron density, generating reactive species responsible for the apoptosis of tumor cells.Samira ElaissiKamel CharradaMDPI AGarticlecold atmospheric plasmafloating electrodecancer therapyatmospheric pressurepulse dischargesimulationEngineering (General). Civil engineering (General)TA1-2040ENCoatings, Vol 11, Iss 1405, p 1405 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cold atmospheric plasma floating electrode cancer therapy atmospheric pressure pulse discharge simulation Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	cold atmospheric plasma floating electrode cancer therapy atmospheric pressure pulse discharge simulation Engineering (General). Civil engineering (General) TA1-2040 Samira Elaissi Kamel Charrada Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis
description	A numerical simulation of a pulsed floating electrode dielectric barrier discharge (FE-DBD) at atmospheric pressure, used for melanoma cancer cell therapy, is performed using a plasma model in COMSOL Multiphysics software. Distributions of electron density, space charge, and electric field are presented at different instants of the pulsed argon discharge. Significant results related to the characteristics of the plasma device used, the inter-electrodes distance, and the power supply are obtained to improve the efficiency of FE-DBD apparatus for melanoma cancer cell treatment. The FE-DBD presents a higher sensitivity to short pulse durations, related to the accumulated charge over the dielectric barrier around the powered electrode. At higher applied voltage, more energy is injected into the discharge channel and an increase in electron density and electric consumed power is noted. Anticancer activity provided by the FE-DBD plasma is improved using a small interelectrode distance with a high electron emission coefficient and a high dielectric constant with a small dielectric thickness, allowing higher electron density, generating reactive species responsible for the apoptosis of tumor cells.
format	article
author	Samira Elaissi Kamel Charrada
author_facet	Samira Elaissi Kamel Charrada
author_sort	Samira Elaissi
title	Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis
title_short	Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis
title_full	Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis
title_fullStr	Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis
title_full_unstemmed	Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis
title_sort	simulation of cold atmospheric plasma generated by floating-electrode dielectric barrier pulsed discharge used for the cancer cell necrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e637948ab01a4e95b6971ba9f3ab97af
work_keys_str_mv	AT samiraelaissi simulationofcoldatmosphericplasmageneratedbyfloatingelectrodedielectricbarrierpulseddischargeusedforthecancercellnecrosis AT kamelcharrada simulationofcoldatmosphericplasmageneratedbyfloatingelectrodedielectricbarrierpulseddischargeusedforthecancercellnecrosis
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Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis

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