MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma

Various studies have manifested that microRNAs (miRNAs) are involved in the modulation of the occurrence and development of osteosarcoma (OS). However, whether miR-22-3p is associated with OS growth remains unclear. In the study, the potential molecular mechanisms of miR-22-3p in OS was explored. It...

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Autores principales:	YuanLiang Xue, Ya Guo, Ning Liu, Zexiang Deng, Yanping Jian, Hongwei Cai, XiangQi Meng
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	microrna-22-3p transcription factor 7-like 2 osteosarcoma wnt/β-catenin proliferation Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/e637dfe03a4c40dc8538721a470a6000
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spelling	oai:doaj.org-article:e637dfe03a4c40dc8538721a470a60002021-11-11T14:23:43ZMicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma2165-59792165-598710.1080/21655979.2021.2003942https://doaj.org/article/e637dfe03a4c40dc8538721a470a60002021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2003942https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Various studies have manifested that microRNAs (miRNAs) are involved in the modulation of the occurrence and development of osteosarcoma (OS). However, whether miR-22-3p is associated with OS growth remains unclear. In the study, the potential molecular mechanisms of miR-22-3p in OS was explored. It was affirmed that miR-22-3p was associated with distant metastasis and tumor size in OS patients, and reduced in OS tissues and cells while transcription factor 7-like 2 (TCF7L2) was elevated. Elevated miR-22-3p repressed OS cell progression, and the Wnt/β-catenin pathway, while elevated TCF7L2 was opposite. MiR-22-3p targeted TCF7L2 in OS. In functional rescue experiments, knockdown of miR-22-3p on OS progression and promotion of Wnt/β-catenin were reversed by simultaneous knockdown of TCF7L2. Transplantation experiments in nude mice showed that elevated miR-22-3p repressed OS tumor growth and decreased TCF7L2, Wnt and β-catenin. Shortly, this study suggest that miR-22-3p refrains the Wnt/β-catenin pathway by targeting TCF7L2 and thereby preventing OS deterioration. MiR-22-3p/TCF7L2 axis is supposed to be a candidate molecular target for future OS treatment.YuanLiang XueYa GuoNing LiuZexiang DengYanping JianHongwei CaiXiangQi MengTaylor & Francis Grouparticlemicrorna-22-3ptranscription factor 7-like 2osteosarcomawnt/β-cateninproliferationBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microrna-22-3p transcription factor 7-like 2 osteosarcoma wnt/β-catenin proliferation Biotechnology TP248.13-248.65
spellingShingle	microrna-22-3p transcription factor 7-like 2 osteosarcoma wnt/β-catenin proliferation Biotechnology TP248.13-248.65 YuanLiang Xue Ya Guo Ning Liu Zexiang Deng Yanping Jian Hongwei Cai XiangQi Meng MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
description	Various studies have manifested that microRNAs (miRNAs) are involved in the modulation of the occurrence and development of osteosarcoma (OS). However, whether miR-22-3p is associated with OS growth remains unclear. In the study, the potential molecular mechanisms of miR-22-3p in OS was explored. It was affirmed that miR-22-3p was associated with distant metastasis and tumor size in OS patients, and reduced in OS tissues and cells while transcription factor 7-like 2 (TCF7L2) was elevated. Elevated miR-22-3p repressed OS cell progression, and the Wnt/β-catenin pathway, while elevated TCF7L2 was opposite. MiR-22-3p targeted TCF7L2 in OS. In functional rescue experiments, knockdown of miR-22-3p on OS progression and promotion of Wnt/β-catenin were reversed by simultaneous knockdown of TCF7L2. Transplantation experiments in nude mice showed that elevated miR-22-3p repressed OS tumor growth and decreased TCF7L2, Wnt and β-catenin. Shortly, this study suggest that miR-22-3p refrains the Wnt/β-catenin pathway by targeting TCF7L2 and thereby preventing OS deterioration. MiR-22-3p/TCF7L2 axis is supposed to be a candidate molecular target for future OS treatment.
format	article
author	YuanLiang Xue Ya Guo Ning Liu Zexiang Deng Yanping Jian Hongwei Cai XiangQi Meng
author_facet	YuanLiang Xue Ya Guo Ning Liu Zexiang Deng Yanping Jian Hongwei Cai XiangQi Meng
author_sort	YuanLiang Xue
title	MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
title_short	MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
title_full	MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
title_fullStr	MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
title_full_unstemmed	MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
title_sort	microrna-22-3p targeted regulating transcription factor 7-like 2 (tcf7l2) constrains the wnt/β-catenin pathway and malignant behavior in osteosarcoma
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/e637dfe03a4c40dc8538721a470a6000
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MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma

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