Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation

It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament mediated vesicle trafficking and endoderm formation....

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Autores principales: Zhaoting Liu, Guozhu Ning, Ranran Xu, Yu Cao, Anming Meng, Qiang Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e63bec7aa7c14c579fd97a93bc75d09f
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