Effect of Betadine on wound healing in rat

BACKGROUND & OBJECTIVE: Betadine is a disinfectant routinely used in all of the Iranian health centers and many other countries in the world but its effect on wound healing is controversial. The aim of this study was to investigate the effect of betadine on wound healing in rat.METHODS: In this...

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Autores principales:	R Tavakoli, F Nabi Pour, H Najafi Pour
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2006
Materias:	betadine wound healing rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e643526856fc4260bf3e5f049c4704ef
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spelling	oai:doaj.org-article:e643526856fc4260bf3e5f049c4704ef2021-11-10T09:12:49ZEffect of Betadine on wound healing in rat1561-41072251-7170https://doaj.org/article/e643526856fc4260bf3e5f049c4704ef2006-06-01T00:00:00Zhttp://jbums.org/article-1-2527-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND & OBJECTIVE: Betadine is a disinfectant routinely used in all of the Iranian health centers and many other countries in the world but its effect on wound healing is controversial. The aim of this study was to investigate the effect of betadine on wound healing in rat.METHODS: In this interventional study, two groups of rats (n=10 each) were randomized as betadine and control groups. Under nesdonal anesthesia, a full thickness skin in an area of 2 cm2 was excised on dorsal neck of rats and immediately betadine was applied in betadine group. Control group received no treatment. Wound area, percentage of recovery and body weight were measured on postoperative days 1, 4, 7 and 10. Number of fibroblasts, collagen fibers, new vessels, lymphocytes, macrophages, neutrophils and thickness of epiderm were determined in three groups by biopsy on day 10.FINDINGS: The results showed the percentage of recovery was not significantly different in the 4th, 7th and 10th days. Revascularisation, fibroblasts, lymphocytes, neutrophils, epidermal depth and collagen fibers were not significantly different between two groups. Macrophages in the betadine group were significantly higher than control group (p<0.01).CONCLUSON: The results propose that betadine not only does not speed up wound healing but also delays the inflammatory phase.R TavakoliF Nabi PourH Najafi PourBabol University of Medical Sciencesarticlebetadinewound healingratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 8, Iss 3, Pp 7-12 (2006)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	betadine wound healing rat Medicine R Medicine (General) R5-920
spellingShingle	betadine wound healing rat Medicine R Medicine (General) R5-920 R Tavakoli F Nabi Pour H Najafi Pour Effect of Betadine on wound healing in rat
description	BACKGROUND & OBJECTIVE: Betadine is a disinfectant routinely used in all of the Iranian health centers and many other countries in the world but its effect on wound healing is controversial. The aim of this study was to investigate the effect of betadine on wound healing in rat.METHODS: In this interventional study, two groups of rats (n=10 each) were randomized as betadine and control groups. Under nesdonal anesthesia, a full thickness skin in an area of 2 cm2 was excised on dorsal neck of rats and immediately betadine was applied in betadine group. Control group received no treatment. Wound area, percentage of recovery and body weight were measured on postoperative days 1, 4, 7 and 10. Number of fibroblasts, collagen fibers, new vessels, lymphocytes, macrophages, neutrophils and thickness of epiderm were determined in three groups by biopsy on day 10.FINDINGS: The results showed the percentage of recovery was not significantly different in the 4th, 7th and 10th days. Revascularisation, fibroblasts, lymphocytes, neutrophils, epidermal depth and collagen fibers were not significantly different between two groups. Macrophages in the betadine group were significantly higher than control group (p<0.01).CONCLUSON: The results propose that betadine not only does not speed up wound healing but also delays the inflammatory phase.
format	article
author	R Tavakoli F Nabi Pour H Najafi Pour
author_facet	R Tavakoli F Nabi Pour H Najafi Pour
author_sort	R Tavakoli
title	Effect of Betadine on wound healing in rat
title_short	Effect of Betadine on wound healing in rat
title_full	Effect of Betadine on wound healing in rat
title_fullStr	Effect of Betadine on wound healing in rat
title_full_unstemmed	Effect of Betadine on wound healing in rat
title_sort	effect of betadine on wound healing in rat
publisher	Babol University of Medical Sciences
publishDate	2006
url	https://doaj.org/article/e643526856fc4260bf3e5f049c4704ef
work_keys_str_mv	AT rtavakoli effectofbetadineonwoundhealinginrat AT fnabipour effectofbetadineonwoundhealinginrat AT hnajafipour effectofbetadineonwoundhealinginrat
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Effect of Betadine on wound healing in rat

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