Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Abstract Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis, and the aim of this study was to determine whether serum hepcidin levels are correlated with the degree...

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Autores principales:	Hiroe Sato, Chinatsu Takai, Junichiro James Kazama, Ayako Wakamatsu, Eriko Hasegawa, Daisuke Kobayashi, Naoki Kondo, Takeshi Nakatsue, Asami Abe, Satoshi Ito, Hajime Ishikawa, Takeshi Kuroda, Yoshiki Suzuki, Ichiei Narita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e643e4fb91bf4a0e9a917114e07306d6
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spelling	oai:doaj.org-article:e643e4fb91bf4a0e9a917114e07306d62021-12-02T17:41:07ZSerum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis10.1038/s41598-020-66945-32045-2322https://doaj.org/article/e643e4fb91bf4a0e9a917114e07306d62020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66945-3https://doaj.org/toc/2045-2322Abstract Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis, and the aim of this study was to determine whether serum hepcidin levels are correlated with the degree of osteoporosis in patients with rheumatoid arthritis (RA). A total of 262 patients with RA (67.5 ± 11.4 years; 77.5% female) were enrolled. Serum iron, ferritin, and hepcidin levels were positively correlated each other. Multiple regression analyses revealed that the serum iron level was positively correlated with femoral T and Z scores, whereas the serum hepcidin level was not. Serum hepcidin level was correlated with the serum 25-hydroxy vitamin D level, which was in turn positively related to the femoral Z score. Serum hepcidin and serum iron were indirectly and directly related to osteoporosis in patients with RA.Hiroe SatoChinatsu TakaiJunichiro James KazamaAyako WakamatsuEriko HasegawaDaisuke KobayashiNaoki KondoTakeshi NakatsueAsami AbeSatoshi ItoHajime IshikawaTakeshi KurodaYoshiki SuzukiIchiei NaritaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroe Sato Chinatsu Takai Junichiro James Kazama Ayako Wakamatsu Eriko Hasegawa Daisuke Kobayashi Naoki Kondo Takeshi Nakatsue Asami Abe Satoshi Ito Hajime Ishikawa Takeshi Kuroda Yoshiki Suzuki Ichiei Narita Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
description	Abstract Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis, and the aim of this study was to determine whether serum hepcidin levels are correlated with the degree of osteoporosis in patients with rheumatoid arthritis (RA). A total of 262 patients with RA (67.5 ± 11.4 years; 77.5% female) were enrolled. Serum iron, ferritin, and hepcidin levels were positively correlated each other. Multiple regression analyses revealed that the serum iron level was positively correlated with femoral T and Z scores, whereas the serum hepcidin level was not. Serum hepcidin level was correlated with the serum 25-hydroxy vitamin D level, which was in turn positively related to the femoral Z score. Serum hepcidin and serum iron were indirectly and directly related to osteoporosis in patients with RA.
format	article
author	Hiroe Sato Chinatsu Takai Junichiro James Kazama Ayako Wakamatsu Eriko Hasegawa Daisuke Kobayashi Naoki Kondo Takeshi Nakatsue Asami Abe Satoshi Ito Hajime Ishikawa Takeshi Kuroda Yoshiki Suzuki Ichiei Narita
author_facet	Hiroe Sato Chinatsu Takai Junichiro James Kazama Ayako Wakamatsu Eriko Hasegawa Daisuke Kobayashi Naoki Kondo Takeshi Nakatsue Asami Abe Satoshi Ito Hajime Ishikawa Takeshi Kuroda Yoshiki Suzuki Ichiei Narita
author_sort	Hiroe Sato
title	Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
title_short	Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
title_full	Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
title_fullStr	Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
title_full_unstemmed	Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
title_sort	serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e643e4fb91bf4a0e9a917114e07306d6
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Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

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