REST regulates the cell cycle for cardiac development and regeneration

The mechanisms regulating cardiomyocyte proliferation during development and cardiac regeneration are incompletely understood. The authors show that the transcription factor REST regulates cardiomyocyte proliferation by binding and repressing the cell cycle inhibitor p21.

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Autores principales:	Donghong Zhang, Yidong Wang, Pengfei Lu, Ping Wang, Xinchun Yuan, Jianyun Yan, Chenleng Cai, Ching-Pin Chang, Deyou Zheng, Bingruo Wu, Bin Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e644a613cf9c426ab48c288f78e91a5e
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spelling	oai:doaj.org-article:e644a613cf9c426ab48c288f78e91a5e2021-12-02T17:01:17ZREST regulates the cell cycle for cardiac development and regeneration10.1038/s41467-017-02210-y2041-1723https://doaj.org/article/e644a613cf9c426ab48c288f78e91a5e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02210-yhttps://doaj.org/toc/2041-1723The mechanisms regulating cardiomyocyte proliferation during development and cardiac regeneration are incompletely understood. The authors show that the transcription factor REST regulates cardiomyocyte proliferation by binding and repressing the cell cycle inhibitor p21.Donghong ZhangYidong WangPengfei LuPing WangXinchun YuanJianyun YanChenleng CaiChing-Pin ChangDeyou ZhengBingruo WuBin ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Donghong Zhang Yidong Wang Pengfei Lu Ping Wang Xinchun Yuan Jianyun Yan Chenleng Cai Ching-Pin Chang Deyou Zheng Bingruo Wu Bin Zhou REST regulates the cell cycle for cardiac development and regeneration
description	The mechanisms regulating cardiomyocyte proliferation during development and cardiac regeneration are incompletely understood. The authors show that the transcription factor REST regulates cardiomyocyte proliferation by binding and repressing the cell cycle inhibitor p21.
format	article
author	Donghong Zhang Yidong Wang Pengfei Lu Ping Wang Xinchun Yuan Jianyun Yan Chenleng Cai Ching-Pin Chang Deyou Zheng Bingruo Wu Bin Zhou
author_facet	Donghong Zhang Yidong Wang Pengfei Lu Ping Wang Xinchun Yuan Jianyun Yan Chenleng Cai Ching-Pin Chang Deyou Zheng Bingruo Wu Bin Zhou
author_sort	Donghong Zhang
title	REST regulates the cell cycle for cardiac development and regeneration
title_short	REST regulates the cell cycle for cardiac development and regeneration
title_full	REST regulates the cell cycle for cardiac development and regeneration
title_fullStr	REST regulates the cell cycle for cardiac development and regeneration
title_full_unstemmed	REST regulates the cell cycle for cardiac development and regeneration
title_sort	rest regulates the cell cycle for cardiac development and regeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e644a613cf9c426ab48c288f78e91a5e
work_keys_str_mv	AT donghongzhang restregulatesthecellcycleforcardiacdevelopmentandregeneration AT yidongwang restregulatesthecellcycleforcardiacdevelopmentandregeneration AT pengfeilu restregulatesthecellcycleforcardiacdevelopmentandregeneration AT pingwang restregulatesthecellcycleforcardiacdevelopmentandregeneration AT xinchunyuan restregulatesthecellcycleforcardiacdevelopmentandregeneration AT jianyunyan restregulatesthecellcycleforcardiacdevelopmentandregeneration AT chenlengcai restregulatesthecellcycleforcardiacdevelopmentandregeneration AT chingpinchang restregulatesthecellcycleforcardiacdevelopmentandregeneration AT deyouzheng restregulatesthecellcycleforcardiacdevelopmentandregeneration AT bingruowu restregulatesthecellcycleforcardiacdevelopmentandregeneration AT binzhou restregulatesthecellcycleforcardiacdevelopmentandregeneration
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REST regulates the cell cycle for cardiac development and regeneration

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