Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood. Modifications on RNA are involved in many pathophysiological processes, such as tumor deve...

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Autores principales:	Xing-xing Huo, Shu-jie Wang, Hang Song, Ming-de Li, Hua Yu, Meng Wang, Hong-xiao Gong, Xiao-ting Qiu, Yong-fu Zhu, Jian-ye Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	RNA modification N 6-methyladenosine N 1-methyladenosine alternative polyadenylation adenosine-to-inosine editing head and neck squamous cell carcinoma Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e646ac9ab3b74495bf2b15c0454adea9
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spelling	oai:doaj.org-article:e646ac9ab3b74495bf2b15c0454adea92021-12-01T02:54:36ZRoles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma1663-981210.3389/fphar.2021.779779https://doaj.org/article/e646ac9ab3b74495bf2b15c0454adea92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.779779/fullhttps://doaj.org/toc/1663-9812Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood. Modifications on RNA are involved in many pathophysiological processes, such as tumor development and inflammation. Adenosine-related RNA modifications have shown to be linked to cancer and may play a role in cancer occurrence and development. To date, there are at least 170 different chemical RNA modifications that modify coding and non-coding RNAs (ncRNAs). These modifications affect RNA stability and transcription efficiency. In this review, we focus on the current understanding of the four major RNA adenosine modifications (N6-Methyladenosine, N1-Methyladenosine, Alternative Polyadenylation Modification and A-to-I RNA editing) and their potential molecular mechanisms related to HNSCC development and progression. We also touch on how these RNA modifications affect treatment of HNSCCs.Xing-xing HuoXing-xing HuoShu-jie WangHang SongMing-de LiHua YuMeng WangHong-xiao GongXiao-ting QiuYong-fu ZhuJian-ye ZhangFrontiers Media S.A.articleRNA modificationN 6-methyladenosineN 1-methyladenosinealternative polyadenylationadenosine-to-inosine editinghead and neck squamous cell carcinomaTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNA modification N 6-methyladenosine N 1-methyladenosine alternative polyadenylation adenosine-to-inosine editing head and neck squamous cell carcinoma Therapeutics. Pharmacology RM1-950
spellingShingle	RNA modification N 6-methyladenosine N 1-methyladenosine alternative polyadenylation adenosine-to-inosine editing head and neck squamous cell carcinoma Therapeutics. Pharmacology RM1-950 Xing-xing Huo Xing-xing Huo Shu-jie Wang Hang Song Ming-de Li Hua Yu Meng Wang Hong-xiao Gong Xiao-ting Qiu Yong-fu Zhu Jian-ye Zhang Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
description	Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood. Modifications on RNA are involved in many pathophysiological processes, such as tumor development and inflammation. Adenosine-related RNA modifications have shown to be linked to cancer and may play a role in cancer occurrence and development. To date, there are at least 170 different chemical RNA modifications that modify coding and non-coding RNAs (ncRNAs). These modifications affect RNA stability and transcription efficiency. In this review, we focus on the current understanding of the four major RNA adenosine modifications (N6-Methyladenosine, N1-Methyladenosine, Alternative Polyadenylation Modification and A-to-I RNA editing) and their potential molecular mechanisms related to HNSCC development and progression. We also touch on how these RNA modifications affect treatment of HNSCCs.
format	article
author	Xing-xing Huo Xing-xing Huo Shu-jie Wang Hang Song Ming-de Li Hua Yu Meng Wang Hong-xiao Gong Xiao-ting Qiu Yong-fu Zhu Jian-ye Zhang
author_facet	Xing-xing Huo Xing-xing Huo Shu-jie Wang Hang Song Ming-de Li Hua Yu Meng Wang Hong-xiao Gong Xiao-ting Qiu Yong-fu Zhu Jian-ye Zhang
author_sort	Xing-xing Huo
title	Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
title_short	Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
title_full	Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
title_fullStr	Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed	Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
title_sort	roles of major rna adenosine modifications in head and neck squamous cell carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e646ac9ab3b74495bf2b15c0454adea9
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Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

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