Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease

Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease

Yang-Pei Chang,1 Mei-Chuan Chou,1–3 Chiou-Lian Lai,2,4–5 I Chien,1 Yuan-Han Yang1,21Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical U...

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Autores principales: Chang YP, Chou MC, Lai CL, Chien I, Yang YH
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Alzheimer’s disease
Extrapyramidal symptoms
Apolipoprotein E e4
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/e646faefbbf747609c11839bd291f974
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spelling oai:doaj.org-article:e646faefbbf747609c11839bd291f9742021-12-02T07:07:46ZApolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease1178-2021https://doaj.org/article/e646faefbbf747609c11839bd291f9742019-07-01T00:00:00Zhttps://www.dovepress.com/apolipoprotein-e-e4-allele-is-associated-with-extrapyramidal-symptoms--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yang-Pei Chang,1 Mei-Chuan Chou,1–3 Chiou-Lian Lai,2,4–5 I Chien,1 Yuan-Han Yang1,21Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; 4Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanBackground: Extrapyramidal symptoms (EPS) are not uncommon in Alzheimer’s disease (AD). As apolipoprotein E(APOE) e4 allele is a major risk factor for late-onset AD, we intend to examine the association between APOE genotype and the development of EPS in AD.Method: This study describes two hundred and fifty-five clinically diagnosed AD patients aged 72 to 80 years from 2010 to 2014. We reviewed the medical charts to determine the development of EPS. APOE genotypes were also confirmed.Results: APOE e4 allele was detected in 74 patients (29%) and rigidity was among the most common EPS (61%). After adjusting the age, gender, baseline clinical dementia rating, we found AD patients carrying APOE e4 allele are more likely to develop EPS (OR: 4.515, p=0.033).Conclusion: This study demonstrates the higher coexistence of EPS in AD patients with APOE e4 allele. Furthermore, the identification of APOE e4 allele in the development of EPS in AD patients supports the hypothesis that EPS may be partially attributed to AD pathology.Keywords: Alzheimer’s disease, extrapyramidal symptoms, apolipoprotein e e4Chang YPChou MCLai CLChien IYang YHDove Medical PressarticleAlzheimer’s diseaseExtrapyramidal symptomsApolipoprotein E e4Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1915-1919 (2019)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer’s disease
Extrapyramidal symptoms
Apolipoprotein E e4
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Alzheimer’s disease
Extrapyramidal symptoms
Apolipoprotein E e4
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Chang YP
Chou MC
Lai CL
Chien I
Yang YH
Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
description Yang-Pei Chang,1 Mei-Chuan Chou,1–3 Chiou-Lian Lai,2,4–5 I Chien,1 Yuan-Han Yang1,21Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; 4Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanBackground: Extrapyramidal symptoms (EPS) are not uncommon in Alzheimer’s disease (AD). As apolipoprotein E(APOE) e4 allele is a major risk factor for late-onset AD, we intend to examine the association between APOE genotype and the development of EPS in AD.Method: This study describes two hundred and fifty-five clinically diagnosed AD patients aged 72 to 80 years from 2010 to 2014. We reviewed the medical charts to determine the development of EPS. APOE genotypes were also confirmed.Results: APOE e4 allele was detected in 74 patients (29%) and rigidity was among the most common EPS (61%). After adjusting the age, gender, baseline clinical dementia rating, we found AD patients carrying APOE e4 allele are more likely to develop EPS (OR: 4.515, p=0.033).Conclusion: This study demonstrates the higher coexistence of EPS in AD patients with APOE e4 allele. Furthermore, the identification of APOE e4 allele in the development of EPS in AD patients supports the hypothesis that EPS may be partially attributed to AD pathology.Keywords: Alzheimer’s disease, extrapyramidal symptoms, apolipoprotein e e4
format article
author Chang YP
Chou MC
Lai CL
Chien I
Yang YH
author_facet Chang YP
Chou MC
Lai CL
Chien I
Yang YH
author_sort Chang YP
title Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
title_short Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
title_full Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
title_fullStr Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
title_full_unstemmed Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
title_sort apolipoprotein e e4 allele is associated with extrapyramidal symptoms in alzheimer’s disease
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/e646faefbbf747609c11839bd291f974
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AT laicl apolipoproteinee4alleleisassociatedwithextrapyramidalsymptomsinalzheimerrsquosdisease
AT chieni apolipoproteinee4alleleisassociatedwithextrapyramidalsymptomsinalzheimerrsquosdisease
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