N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model

Concussions and mild traumatic brain injury (m-TBI) have been identified as a consequential public health concern because of their potential to cause considerable impairments in physical, cognitive, behavioral, and social functions. Given their prominent structural and functional roles in the brain,...

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Autores principales:	Jessica-Dominique Lecques, Brynna J. K. Kerr, Lyn M. Hillyer, Jing X. Kang, Lindsay E. Robinson, David W. L. Ma
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	concussion mild traumatic brain injury TBI n-3 PUFA neurological sensitivity score Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e64da5a994924ac999d69b7717c9927d
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spelling	oai:doaj.org-article:e64da5a994924ac999d69b7717c9927d2021-11-25T18:36:42ZN-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model10.3390/nu131140922072-6643https://doaj.org/article/e64da5a994924ac999d69b7717c9927d2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4092https://doaj.org/toc/2072-6643Concussions and mild traumatic brain injury (m-TBI) have been identified as a consequential public health concern because of their potential to cause considerable impairments in physical, cognitive, behavioral, and social functions. Given their prominent structural and functional roles in the brain, n-3 polyunsaturated fatty acids (PUFA) have been identified as a potentially viable prophylactic agent that may ameliorate the deleterious effects of m-TBI on brain function. The purpose of the present pilot study was to investigate the effect of n-3 PUFA on neurologic function using a weight drop injury (WDI) model. <i>Fat-1</i> mice, capable of synthesizing n-3 PUFA endogenously from n-6 PUFA, and their wild-type (WT) counterparts, were subjected to a mild low-impact WDI on the closed cranium, and recovery was evaluated using the neurological severity score (NSS) to assess the motor and neurobehavioral outcomes. In comparison to the WT mice, the <i>fat-1</i> mice had a significantly (<i>p</i> ≤ 0.05) lower NSS at all time points post-WDI, and significantly greater neurological restoration measured as the time to first movement. Overall, these findings demonstrate the protective effect of n-3 PUFA against mild brain injury.Jessica-Dominique LecquesBrynna J. K. KerrLyn M. HillyerJing X. KangLindsay E. RobinsonDavid W. L. MaMDPI AGarticleconcussionmild traumatic brain injuryTBIn-3 PUFAneurological sensitivity scoreNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4092, p 4092 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	concussion mild traumatic brain injury TBI n-3 PUFA neurological sensitivity score Nutrition. Foods and food supply TX341-641
spellingShingle	concussion mild traumatic brain injury TBI n-3 PUFA neurological sensitivity score Nutrition. Foods and food supply TX341-641 Jessica-Dominique Lecques Brynna J. K. Kerr Lyn M. Hillyer Jing X. Kang Lindsay E. Robinson David W. L. Ma N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model
description	Concussions and mild traumatic brain injury (m-TBI) have been identified as a consequential public health concern because of their potential to cause considerable impairments in physical, cognitive, behavioral, and social functions. Given their prominent structural and functional roles in the brain, n-3 polyunsaturated fatty acids (PUFA) have been identified as a potentially viable prophylactic agent that may ameliorate the deleterious effects of m-TBI on brain function. The purpose of the present pilot study was to investigate the effect of n-3 PUFA on neurologic function using a weight drop injury (WDI) model. <i>Fat-1</i> mice, capable of synthesizing n-3 PUFA endogenously from n-6 PUFA, and their wild-type (WT) counterparts, were subjected to a mild low-impact WDI on the closed cranium, and recovery was evaluated using the neurological severity score (NSS) to assess the motor and neurobehavioral outcomes. In comparison to the WT mice, the <i>fat-1</i> mice had a significantly (<i>p</i> ≤ 0.05) lower NSS at all time points post-WDI, and significantly greater neurological restoration measured as the time to first movement. Overall, these findings demonstrate the protective effect of n-3 PUFA against mild brain injury.
format	article
author	Jessica-Dominique Lecques Brynna J. K. Kerr Lyn M. Hillyer Jing X. Kang Lindsay E. Robinson David W. L. Ma
author_facet	Jessica-Dominique Lecques Brynna J. K. Kerr Lyn M. Hillyer Jing X. Kang Lindsay E. Robinson David W. L. Ma
author_sort	Jessica-Dominique Lecques
title	N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model
title_short	N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model
title_full	N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model
title_fullStr	N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model
title_full_unstemmed	N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model
title_sort	n-3 polyunsaturated fatty acids ameliorate neurobehavioral outcomes post-mild traumatic brain injury in the <i>fat-1</i> mouse model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e64da5a994924ac999d69b7717c9927d
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N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the <i>Fat-1</i> Mouse Model

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