Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects

Abstract [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients....

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Autores principales:	Mai Hatano, Tomoyuki Miyazaki, Yoshinobu Ishiwata, Waki Nakajima, Tetsu Arisawa, Yoko Kuroki, Ayako Kobayashi, Yuuki Takada, Matsuyoshi Ogawa, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi, Masataka Taguri, Yasuyuki Kimura, Takuya Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e64e9318174b4b25acffef4f39849587
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spelling	oai:doaj.org-article:e64e9318174b4b25acffef4f398495872021-12-02T14:01:21ZBiodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects10.1038/s41598-021-81002-32045-2322https://doaj.org/article/e64e9318174b4b25acffef4f398495872021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81002-3https://doaj.org/toc/2045-2322Abstract [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients. This study aimed to estimate the radiation doses of [11C]K-2 in various organs and calculate the effective dose after injection of [11C]K-2 in healthy human subjects. Twelve healthy male subjects were registered and divided into two groups (370 or 555 MBq of [11C]K-2), followed by 2 h whole-body scans. We estimated the radiation dose of each organ and then calculated the effective dose for each subject. The highest uptake of [11C]K-2 was observed in the liver, while the brain also showed relatively high uptake. The urinary bladder exhibited the highest radiation dose. The kidneys and liver also showed high radiation doses after [11C]K-2 injections. The effective dose of [11C]K-2 ranged from 5.0 to 5.2 μSv/MBq. Our findings suggest that [11C]K-2 is safe in terms of the radiation dose and adverse effects. The injection of 370–555 MBq (10 to 15 mCi) for PET studies using this radiotracer is applicable in healthy human subjects and enables serial PET scans in a single subject.Mai HatanoTomoyuki MiyazakiYoshinobu IshiwataWaki NakajimaTetsu ArisawaYoko KurokiAyako KobayashiYuuki TakadaMatsuyoshi OgawaKazunori KawamuraMing-Rong ZhangMakoto HiguchiMasataka TaguriYasuyuki KimuraTakuya TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mai Hatano Tomoyuki Miyazaki Yoshinobu Ishiwata Waki Nakajima Tetsu Arisawa Yoko Kuroki Ayako Kobayashi Yuuki Takada Matsuyoshi Ogawa Kazunori Kawamura Ming-Rong Zhang Makoto Higuchi Masataka Taguri Yasuyuki Kimura Takuya Takahashi Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
description	Abstract [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients. This study aimed to estimate the radiation doses of [11C]K-2 in various organs and calculate the effective dose after injection of [11C]K-2 in healthy human subjects. Twelve healthy male subjects were registered and divided into two groups (370 or 555 MBq of [11C]K-2), followed by 2 h whole-body scans. We estimated the radiation dose of each organ and then calculated the effective dose for each subject. The highest uptake of [11C]K-2 was observed in the liver, while the brain also showed relatively high uptake. The urinary bladder exhibited the highest radiation dose. The kidneys and liver also showed high radiation doses after [11C]K-2 injections. The effective dose of [11C]K-2 ranged from 5.0 to 5.2 μSv/MBq. Our findings suggest that [11C]K-2 is safe in terms of the radiation dose and adverse effects. The injection of 370–555 MBq (10 to 15 mCi) for PET studies using this radiotracer is applicable in healthy human subjects and enables serial PET scans in a single subject.
format	article
author	Mai Hatano Tomoyuki Miyazaki Yoshinobu Ishiwata Waki Nakajima Tetsu Arisawa Yoko Kuroki Ayako Kobayashi Yuuki Takada Matsuyoshi Ogawa Kazunori Kawamura Ming-Rong Zhang Makoto Higuchi Masataka Taguri Yasuyuki Kimura Takuya Takahashi
author_facet	Mai Hatano Tomoyuki Miyazaki Yoshinobu Ishiwata Waki Nakajima Tetsu Arisawa Yoko Kuroki Ayako Kobayashi Yuuki Takada Matsuyoshi Ogawa Kazunori Kawamura Ming-Rong Zhang Makoto Higuchi Masataka Taguri Yasuyuki Kimura Takuya Takahashi
author_sort	Mai Hatano
title	Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
title_short	Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
title_full	Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
title_fullStr	Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
title_full_unstemmed	Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
title_sort	biodistribution and radiation dosimetry of the positron emission tomography probe for ampa receptor, [11c]k-2, in healthy human subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e64e9318174b4b25acffef4f39849587
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Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects

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