Slow viral propagation during initial phase of infection leads to viral persistence in mice

Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as a mechanism for immune evasion and viral persiste...

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Autores principales:	Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
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spelling	oai:doaj.org-article:e64f13b539b04accba130bd3d10b58442021-12-02T17:39:18ZSlow viral propagation during initial phase of infection leads to viral persistence in mice10.1038/s42003-021-02028-x2399-3642https://doaj.org/article/e64f13b539b04accba130bd3d10b58442021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02028-xhttps://doaj.org/toc/2399-3642Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as a mechanism for immune evasion and viral persistence.Haifeng C. XuRuifeng WangPrashant V. ShindeLara WalotkaAnfei HuangGereon PoschmannJun HuangWei LiuKai StühlerHeiner SchaalAndreas BergthalerAleksandra A. PandyraCornelia HardtKarl S. LangPhilipp A. LangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Haifeng C. Xu Ruifeng Wang Prashant V. Shinde Lara Walotka Anfei Huang Gereon Poschmann Jun Huang Wei Liu Kai Stühler Heiner Schaal Andreas Bergthaler Aleksandra A. Pandyra Cornelia Hardt Karl S. Lang Philipp A. Lang Slow viral propagation during initial phase of infection leads to viral persistence in mice
description	Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as a mechanism for immune evasion and viral persistence.
format	article
author	Haifeng C. Xu Ruifeng Wang Prashant V. Shinde Lara Walotka Anfei Huang Gereon Poschmann Jun Huang Wei Liu Kai Stühler Heiner Schaal Andreas Bergthaler Aleksandra A. Pandyra Cornelia Hardt Karl S. Lang Philipp A. Lang
author_facet	Haifeng C. Xu Ruifeng Wang Prashant V. Shinde Lara Walotka Anfei Huang Gereon Poschmann Jun Huang Wei Liu Kai Stühler Heiner Schaal Andreas Bergthaler Aleksandra A. Pandyra Cornelia Hardt Karl S. Lang Philipp A. Lang
author_sort	Haifeng C. Xu
title	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_short	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_full	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_fullStr	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_full_unstemmed	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_sort	slow viral propagation during initial phase of infection leads to viral persistence in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
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Slow viral propagation during initial phase of infection leads to viral persistence in mice

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