Sirtuin-1 in Egyptian patients with coronary artery disease

Abstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma le...

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Autores principales:	AL-Shabrawy M. Abdelnabi, Imam M. Esmayel, Samia Hussein, Reham M. Ali, Alhoussein Alsayed AbdelAal
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Atherosclerosis Coronary heart disease Sirtuin Medicine (General) R5-920 Science Q
Acceso en línea:	https://doaj.org/article/e652993945ae42759ca3b39c90f5dcb2
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spelling	oai:doaj.org-article:e652993945ae42759ca3b39c90f5dcb22021-11-08T10:59:08ZSirtuin-1 in Egyptian patients with coronary artery disease10.1186/s43088-021-00164-12314-8543https://doaj.org/article/e652993945ae42759ca3b39c90f5dcb22021-11-01T00:00:00Zhttps://doi.org/10.1186/s43088-021-00164-1https://doaj.org/toc/2314-8543Abstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors. Results Plasma SIRT1 was significantly lower in patients with chronic coronary syndrome (CCS) than in those in the control group and was significantly lower in patients with both acute myocardial infarction and unstable angina than in those in the control group and with CCS. Moreover, plasma SIRT1 was positively correlated with platelet count and negatively correlated with cholesterol and triglyceride levels. Conclusions The plasma level of SIRT1 is lower in patients with CAD compared to control and it could be a possible marker for this disease. Multi-center studies with follow-up measurements are recommended for further investigation.AL-Shabrawy M. AbdelnabiImam M. EsmayelSamia HusseinReham M. AliAlhoussein Alsayed AbdelAalSpringerOpenarticleAtherosclerosisCoronary heart diseaseSirtuinMedicine (General)R5-920ScienceQENBeni-Suef University Journal of Basic and Applied Sciences, Vol 10, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atherosclerosis Coronary heart disease Sirtuin Medicine (General) R5-920 Science Q
spellingShingle	Atherosclerosis Coronary heart disease Sirtuin Medicine (General) R5-920 Science Q AL-Shabrawy M. Abdelnabi Imam M. Esmayel Samia Hussein Reham M. Ali Alhoussein Alsayed AbdelAal Sirtuin-1 in Egyptian patients with coronary artery disease
description	Abstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors. Results Plasma SIRT1 was significantly lower in patients with chronic coronary syndrome (CCS) than in those in the control group and was significantly lower in patients with both acute myocardial infarction and unstable angina than in those in the control group and with CCS. Moreover, plasma SIRT1 was positively correlated with platelet count and negatively correlated with cholesterol and triglyceride levels. Conclusions The plasma level of SIRT1 is lower in patients with CAD compared to control and it could be a possible marker for this disease. Multi-center studies with follow-up measurements are recommended for further investigation.
format	article
author	AL-Shabrawy M. Abdelnabi Imam M. Esmayel Samia Hussein Reham M. Ali Alhoussein Alsayed AbdelAal
author_facet	AL-Shabrawy M. Abdelnabi Imam M. Esmayel Samia Hussein Reham M. Ali Alhoussein Alsayed AbdelAal
author_sort	AL-Shabrawy M. Abdelnabi
title	Sirtuin-1 in Egyptian patients with coronary artery disease
title_short	Sirtuin-1 in Egyptian patients with coronary artery disease
title_full	Sirtuin-1 in Egyptian patients with coronary artery disease
title_fullStr	Sirtuin-1 in Egyptian patients with coronary artery disease
title_full_unstemmed	Sirtuin-1 in Egyptian patients with coronary artery disease
title_sort	sirtuin-1 in egyptian patients with coronary artery disease
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/e652993945ae42759ca3b39c90f5dcb2
work_keys_str_mv	AT alshabrawymabdelnabi sirtuin1inegyptianpatientswithcoronaryarterydisease AT imammesmayel sirtuin1inegyptianpatientswithcoronaryarterydisease AT samiahussein sirtuin1inegyptianpatientswithcoronaryarterydisease AT rehammali sirtuin1inegyptianpatientswithcoronaryarterydisease AT alhousseinalsayedabdelaal sirtuin1inegyptianpatientswithcoronaryarterydisease
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Sirtuin-1 in Egyptian patients with coronary artery disease

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