HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy

ABSTRACT The HIV epidemics in infants and adolescent women are linked. Young women of childbearing age are at high risk for HIV infection and, due to poor HIV testing rates and low adherence to antiretroviral therapy, are at high risk for mother-to-infant transmission. We hypothesize that HIV vaccin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alan D. Curtis, Maria Dennis, Joshua Eudailey, Korey L. Walter, Kenneth Cronin, S. Munir Alam, Neelima Choudhary, Ryan H. Tuck, Michael Hudgens, Pamela A. Kozlowski, Justin Pollara, Guido Ferrari, Koen K. A. Van Rompay, Sallie Permar, Kristina De Paris
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	HIV pediatric vaccination memory antibody responses adjuvant Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e65405714d164bc481100e10521b969e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e65405714d164bc481100e10521b969e
record_format	dspace
spelling	oai:doaj.org-article:e65405714d164bc481100e10521b969e2021-11-15T15:29:16ZHIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy10.1128/mSphere.00162-202379-5042https://doaj.org/article/e65405714d164bc481100e10521b969e2020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00162-20https://doaj.org/toc/2379-5042ABSTRACT The HIV epidemics in infants and adolescent women are linked. Young women of childbearing age are at high risk for HIV infection and, due to poor HIV testing rates and low adherence to antiretroviral therapy, are at high risk for mother-to-infant transmission. We hypothesize that HIV vaccine regimens initiated in early life would provide the necessary time frame to induce mature and highly functional Env-specific antibody responses that could potentially also protect against HIV acquisition later in life. The present study was designed to test two vaccine regimens, a clade C HIV Env protein vaccine (Env only) alone or combined with a modified vaccinia Ankara (MVA) vector expressing HIV Env (MVA/Env) for the induction and persistence of Env-specific antibody responses in an infant nonhuman primate model. Vaccination was initiated within the first week of life, with booster immunizations at weeks 6, 12, and 32. We demonstrate that both vaccine strategies were able to elicit durable Env-specific antibody responses that were enhanced by a late boost in infancy. Furthermore, we confirmed earlier data that intramuscular administration of the Env protein with the Toll-like receptor 7/8 (TLR7/8)-based adjuvant 3M-052 in stable emulsion (3M-052-SE) induced higher Env-specific antibody responses than vaccination with Env adjuvanted in Span85-Tween 80-squalene (STS) tested in a previous study. These results support the concept of early vaccination as a means to induce durable immune responses that may prevent HIV infection in adolescence at the onset of sexual debut. IMPORTANCE The majority of new HIV-1 infections occur in young adults, with adolescent women being 3 times more likely to acquire HIV than young men. Implementation of HIV prevention strategies has been less successful in this age group; thus, a vaccine given prior to adolescence remains a high priority. We propose that instead of starting HIV vaccination during adolescence, an HIV vaccine regimen initiated in early infancy, aligned with the well-accepted pediatric vaccine schedule and followed with booster immunizations, will provide an alternative means to reduce HIV acquisition in adolescence. Importantly, the long window of time between the first infant vaccine dose and the adolescence vaccine dose will allow for the maturation of highly functional HIV Env-specific antibody responses. Our study provides evidence that early life vaccination induces durable Env-specific plasma IgG responses that can be boosted to further improve the quality of the antibody response.Alan D. CurtisMaria DennisJoshua EudaileyKorey L. WalterKenneth CroninS. Munir AlamNeelima ChoudharyRyan H. TuckMichael HudgensPamela A. KozlowskiJustin PollaraGuido FerrariKoen K. A. Van RompaySallie PermarKristina De ParisAmerican Society for MicrobiologyarticleHIVpediatric vaccinationmemory antibody responsesadjuvantMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV pediatric vaccination memory antibody responses adjuvant Microbiology QR1-502
spellingShingle	HIV pediatric vaccination memory antibody responses adjuvant Microbiology QR1-502 Alan D. Curtis Maria Dennis Joshua Eudailey Korey L. Walter Kenneth Cronin S. Munir Alam Neelima Choudhary Ryan H. Tuck Michael Hudgens Pamela A. Kozlowski Justin Pollara Guido Ferrari Koen K. A. Van Rompay Sallie Permar Kristina De Paris HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
description	ABSTRACT The HIV epidemics in infants and adolescent women are linked. Young women of childbearing age are at high risk for HIV infection and, due to poor HIV testing rates and low adherence to antiretroviral therapy, are at high risk for mother-to-infant transmission. We hypothesize that HIV vaccine regimens initiated in early life would provide the necessary time frame to induce mature and highly functional Env-specific antibody responses that could potentially also protect against HIV acquisition later in life. The present study was designed to test two vaccine regimens, a clade C HIV Env protein vaccine (Env only) alone or combined with a modified vaccinia Ankara (MVA) vector expressing HIV Env (MVA/Env) for the induction and persistence of Env-specific antibody responses in an infant nonhuman primate model. Vaccination was initiated within the first week of life, with booster immunizations at weeks 6, 12, and 32. We demonstrate that both vaccine strategies were able to elicit durable Env-specific antibody responses that were enhanced by a late boost in infancy. Furthermore, we confirmed earlier data that intramuscular administration of the Env protein with the Toll-like receptor 7/8 (TLR7/8)-based adjuvant 3M-052 in stable emulsion (3M-052-SE) induced higher Env-specific antibody responses than vaccination with Env adjuvanted in Span85-Tween 80-squalene (STS) tested in a previous study. These results support the concept of early vaccination as a means to induce durable immune responses that may prevent HIV infection in adolescence at the onset of sexual debut. IMPORTANCE The majority of new HIV-1 infections occur in young adults, with adolescent women being 3 times more likely to acquire HIV than young men. Implementation of HIV prevention strategies has been less successful in this age group; thus, a vaccine given prior to adolescence remains a high priority. We propose that instead of starting HIV vaccination during adolescence, an HIV vaccine regimen initiated in early infancy, aligned with the well-accepted pediatric vaccine schedule and followed with booster immunizations, will provide an alternative means to reduce HIV acquisition in adolescence. Importantly, the long window of time between the first infant vaccine dose and the adolescence vaccine dose will allow for the maturation of highly functional HIV Env-specific antibody responses. Our study provides evidence that early life vaccination induces durable Env-specific plasma IgG responses that can be boosted to further improve the quality of the antibody response.
format	article
author	Alan D. Curtis Maria Dennis Joshua Eudailey Korey L. Walter Kenneth Cronin S. Munir Alam Neelima Choudhary Ryan H. Tuck Michael Hudgens Pamela A. Kozlowski Justin Pollara Guido Ferrari Koen K. A. Van Rompay Sallie Permar Kristina De Paris
author_facet	Alan D. Curtis Maria Dennis Joshua Eudailey Korey L. Walter Kenneth Cronin S. Munir Alam Neelima Choudhary Ryan H. Tuck Michael Hudgens Pamela A. Kozlowski Justin Pollara Guido Ferrari Koen K. A. Van Rompay Sallie Permar Kristina De Paris
author_sort	Alan D. Curtis
title	HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
title_short	HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
title_full	HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
title_fullStr	HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
title_full_unstemmed	HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy
title_sort	hiv env-specific igg antibodies induced by vaccination of neonatal rhesus macaques persist and can be augmented by a late booster immunization in infancy
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/e65405714d164bc481100e10521b969e
work_keys_str_mv	AT alandcurtis hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT mariadennis hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT joshuaeudailey hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT koreylwalter hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT kennethcronin hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT smuniralam hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT neelimachoudhary hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT ryanhtuck hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT michaelhudgens hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT pamelaakozlowski hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT justinpollara hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT guidoferrari hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT koenkavanrompay hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT salliepermar hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy AT kristinadeparis hivenvspecificiggantibodiesinducedbyvaccinationofneonatalrhesusmacaquespersistandcanbeaugmentedbyalateboosterimmunizationininfancy
_version_	1718427921480155136

HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy

Ejemplares similares