Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Abstract To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg...

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Autores principales:	Jasmin Rezapour, Alexander K. Schuster, Stefan Nickels, Christina A. Korb, Hisham Elbaz, Tunde Peto, Matthias Michal, Thomas Münzel, Philipp S. Wild, Jochem König, Karl Lackner, Andreas Schulz, Norbert Pfeiffer, Manfred E. Beutel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6548854ca52425395b0c285c0c16375
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spelling	oai:doaj.org-article:e6548854ca52425395b0c285c0c163752021-12-02T16:31:17ZPrevalence and new onset of depression and anxiety among participants with AMD in a European cohort10.1038/s41598-020-61706-82045-2322https://doaj.org/article/e6548854ca52425395b0c285c0c163752020-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-61706-8https://doaj.org/toc/2045-2322Abstract To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.Jasmin RezapourAlexander K. SchusterStefan NickelsChristina A. KorbHisham ElbazTunde PetoMatthias MichalThomas MünzelPhilipp S. WildJochem KönigKarl LacknerAndreas SchulzNorbert PfeifferManfred E. BeutelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jasmin Rezapour Alexander K. Schuster Stefan Nickels Christina A. Korb Hisham Elbaz Tunde Peto Matthias Michal Thomas Münzel Philipp S. Wild Jochem König Karl Lackner Andreas Schulz Norbert Pfeiffer Manfred E. Beutel Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
description	Abstract To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.
format	article
author	Jasmin Rezapour Alexander K. Schuster Stefan Nickels Christina A. Korb Hisham Elbaz Tunde Peto Matthias Michal Thomas Münzel Philipp S. Wild Jochem König Karl Lackner Andreas Schulz Norbert Pfeiffer Manfred E. Beutel
author_facet	Jasmin Rezapour Alexander K. Schuster Stefan Nickels Christina A. Korb Hisham Elbaz Tunde Peto Matthias Michal Thomas Münzel Philipp S. Wild Jochem König Karl Lackner Andreas Schulz Norbert Pfeiffer Manfred E. Beutel
author_sort	Jasmin Rezapour
title	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
title_short	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
title_full	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
title_fullStr	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
title_full_unstemmed	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
title_sort	prevalence and new onset of depression and anxiety among participants with amd in a european cohort
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6548854ca52425395b0c285c0c16375
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Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

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