HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry

The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain and gain mechanistic insights into the process.

Guardado en:

Detalles Bibliográficos
Autores principales:	Vincent V. Pham, Carolina Salguero, Shamsun Nahar Khan, Jennifer L. Meagher, W. Clay Brown, Nicolas Humbert, Hugues de Rocquigny, Janet L. Smith, Victoria M. D’Souza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6554c00f39b4f589bd46ef921f677e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e6554c00f39b4f589bd46ef921f677e2
record_format	dspace
spelling	oai:doaj.org-article:e6554c00f39b4f589bd46ef921f677e22021-12-02T15:34:22ZHIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry10.1038/s41467-018-06591-62041-1723https://doaj.org/article/e6554c00f39b4f589bd46ef921f677e22018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06591-6https://doaj.org/toc/2041-1723The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain and gain mechanistic insights into the process.Vincent V. PhamCarolina SalgueroShamsun Nahar KhanJennifer L. MeagherW. Clay BrownNicolas HumbertHugues de RocquignyJanet L. SmithVictoria M. D’SouzaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent V. Pham Carolina Salguero Shamsun Nahar Khan Jennifer L. Meagher W. Clay Brown Nicolas Humbert Hugues de Rocquigny Janet L. Smith Victoria M. D’Souza HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry
description	The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain and gain mechanistic insights into the process.
format	article
author	Vincent V. Pham Carolina Salguero Shamsun Nahar Khan Jennifer L. Meagher W. Clay Brown Nicolas Humbert Hugues de Rocquigny Janet L. Smith Victoria M. D’Souza
author_facet	Vincent V. Pham Carolina Salguero Shamsun Nahar Khan Jennifer L. Meagher W. Clay Brown Nicolas Humbert Hugues de Rocquigny Janet L. Smith Victoria M. D’Souza
author_sort	Vincent V. Pham
title	HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry
title_short	HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry
title_full	HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry
title_fullStr	HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry
title_full_unstemmed	HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry
title_sort	hiv-1 tat interactions with cellular 7sk and viral tar rnas identifies dual structural mimicry
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e6554c00f39b4f589bd46ef921f677e2
work_keys_str_mv	AT vincentvpham hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT carolinasalguero hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT shamsunnaharkhan hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT jenniferlmeagher hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT wclaybrown hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT nicolashumbert hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT huguesderocquigny hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT janetlsmith hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry AT victoriamdsouza hiv1tatinteractionswithcellular7skandviraltarrnasidentifiesdualstructuralmimicry
_version_	1718386872437178368

HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry

Ejemplares similares