An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting human tumor cells in targeted tissues of an avian e...

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Autores principales:	Loraine Jarrosson, Clélia Costechareyre, Fanny Gallix, Séverine Ciré, Fabien Gay, Olivier Imbaud, Romain Teinturier, Elisabetta Marangoni, Karine Aguéra, Céline Delloye-Bourgeois, Valérie Castellani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences research methodologies Cancer Model organism Science Q
Acceso en línea:	https://doaj.org/article/e65639efd1b04677a4ab64cc3627fbe5
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spelling	oai:doaj.org-article:e65639efd1b04677a4ab64cc3627fbe52021-11-22T04:28:49ZAn avian embryo patient-derived xenograft model for preclinical studies of human breast cancers2589-004210.1016/j.isci.2021.103423https://doaj.org/article/e65639efd1b04677a4ab64cc3627fbe52021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013948https://doaj.org/toc/2589-0042Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting human tumor cells in targeted tissues of an avian embryo, delivering therapeutics, evaluating their efficacy by measuring tumors using light sheet confocal microscopy, and conducting large-scale RNA-seq analysis to characterize therapeutic-induced changes in gene expression. The model was established to recapitulate triple-negative breast cancer (TNBC) and validated using TNBC standards of care and an investigational therapeutic agent.Loraine JarrossonClélia CostechareyreFanny GallixSéverine CiréFabien GayOlivier ImbaudRomain TeinturierElisabetta MarangoniKarine AguéraCéline Delloye-BourgeoisValérie CastellaniElsevierarticleBiological sciences research methodologiesCancerModel organismScienceQENiScience, Vol 24, Iss 12, Pp 103423- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences research methodologies Cancer Model organism Science Q
spellingShingle	Biological sciences research methodologies Cancer Model organism Science Q Loraine Jarrosson Clélia Costechareyre Fanny Gallix Séverine Ciré Fabien Gay Olivier Imbaud Romain Teinturier Elisabetta Marangoni Karine Aguéra Céline Delloye-Bourgeois Valérie Castellani An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
description	Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting human tumor cells in targeted tissues of an avian embryo, delivering therapeutics, evaluating their efficacy by measuring tumors using light sheet confocal microscopy, and conducting large-scale RNA-seq analysis to characterize therapeutic-induced changes in gene expression. The model was established to recapitulate triple-negative breast cancer (TNBC) and validated using TNBC standards of care and an investigational therapeutic agent.
format	article
author	Loraine Jarrosson Clélia Costechareyre Fanny Gallix Séverine Ciré Fabien Gay Olivier Imbaud Romain Teinturier Elisabetta Marangoni Karine Aguéra Céline Delloye-Bourgeois Valérie Castellani
author_facet	Loraine Jarrosson Clélia Costechareyre Fanny Gallix Séverine Ciré Fabien Gay Olivier Imbaud Romain Teinturier Elisabetta Marangoni Karine Aguéra Céline Delloye-Bourgeois Valérie Castellani
author_sort	Loraine Jarrosson
title	An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
title_short	An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
title_full	An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
title_fullStr	An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
title_full_unstemmed	An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
title_sort	avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e65639efd1b04677a4ab64cc3627fbe5
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An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

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