Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.

<h4>Aim</h4>To determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers.<h4>Methods</h4>Participants in the Mexican Health Worker...

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Autores principales:	Yvonne N Flores, Samantha Toth, Catherine M Crespi, Paula Ramírez-Palacios, William J McCarthy, Arely Briseño-Pérez, Víctor Granados-García, Jorge Salmerón
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e656d0e20d614cdf92419dc6c596fd77
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spelling	oai:doaj.org-article:e656d0e20d614cdf92419dc6c596fd772021-12-02T20:11:29ZRisk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.1932-620310.1371/journal.pone.0229403https://doaj.org/article/e656d0e20d614cdf92419dc6c596fd772020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0229403https://doaj.org/toc/1932-6203<h4>Aim</h4>To determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers.<h4>Methods</h4>Participants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively.<h4>Results</h4>Mean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The cross-sectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among individuals who either maintained or acquired MS, elevated ALT, or elevated uric acid (only for diabetes) from W1 to W2.<h4>Conclusions</h4>Weight gain and acquiring or maintaining MS, elevated ALT levels, or elevated uric acid were associated with a significant risk of developing pre-diabetes or diabetes. Our findings, especially in the context of the obesity epidemic in Mexico, point towards an urgent need for initiatives to help reduce excess weight in order to avert future cases of pre-diabetes and diabetes.Yvonne N FloresSamantha TothCatherine M CrespiPaula Ramírez-PalaciosWilliam J McCarthyArely Briseño-PérezVíctor Granados-GarcíaJorge SalmerónPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 3, p e0229403 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yvonne N Flores Samantha Toth Catherine M Crespi Paula Ramírez-Palacios William J McCarthy Arely Briseño-Pérez Víctor Granados-García Jorge Salmerón Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.
description	<h4>Aim</h4>To determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers.<h4>Methods</h4>Participants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively.<h4>Results</h4>Mean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The cross-sectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among individuals who either maintained or acquired MS, elevated ALT, or elevated uric acid (only for diabetes) from W1 to W2.<h4>Conclusions</h4>Weight gain and acquiring or maintaining MS, elevated ALT levels, or elevated uric acid were associated with a significant risk of developing pre-diabetes or diabetes. Our findings, especially in the context of the obesity epidemic in Mexico, point towards an urgent need for initiatives to help reduce excess weight in order to avert future cases of pre-diabetes and diabetes.
format	article
author	Yvonne N Flores Samantha Toth Catherine M Crespi Paula Ramírez-Palacios William J McCarthy Arely Briseño-Pérez Víctor Granados-García Jorge Salmerón
author_facet	Yvonne N Flores Samantha Toth Catherine M Crespi Paula Ramírez-Palacios William J McCarthy Arely Briseño-Pérez Víctor Granados-García Jorge Salmerón
author_sort	Yvonne N Flores
title	Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.
title_short	Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.
title_full	Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.
title_fullStr	Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.
title_full_unstemmed	Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.
title_sort	risk of developing pre-diabetes or diabetes over time in a cohort of mexican health workers.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/e656d0e20d614cdf92419dc6c596fd77
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Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers.

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