Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons

Abstract Prelimbic cortex and infralimbic cortex, parts of the ventromedial prefrontal cortex, are critical brain regions for generating a flexible behavioral response to changing environmental contingencies. This includes the role of these brain structures in the extinction of learned fear, decisio...

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Autores principales:	Archana Ashokan, Jamien Wee Han Lim, Nicholas Hang, Rupshi Mitra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e656e07222dd4fcbaf00a0c8d3523eb5
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spelling	oai:doaj.org-article:e656e07222dd4fcbaf00a0c8d3523eb52021-12-02T15:08:25ZComplex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons10.1038/s41598-018-25399-42045-2322https://doaj.org/article/e656e07222dd4fcbaf00a0c8d3523eb52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25399-4https://doaj.org/toc/2045-2322Abstract Prelimbic cortex and infralimbic cortex, parts of the ventromedial prefrontal cortex, are critical brain regions for generating a flexible behavioral response to changing environmental contingencies. This includes the role of these brain structures in the extinction of learned fear, decision making and retrieval of remote memories. Dendritic structure of medial prefrontal cortex neurons retains significant structural plasticity in adulthood. This has been mainly demonstrated as dendritic atrophy and loss of dendritic spines due to chronic stress. It remains unknown if housing condition of the animals itself can cause opposing changes in the dendritic organization. In that backdrop, here we report that short-term increase in complexity of the housing causes a robust increase in complexity of dendritic architecture of prelimbic and infralimbic neurons. This is reflected in the dendritic expansion of prelimbic neurons and increase in spine density of prelimbic and infralimbic neurons. These results suggest that non-invasive changes in the housing environment can be harnessed to study brain reserves for the flexible and species-typical behaviors.Archana AshokanJamien Wee Han LimNicholas HangRupshi MitraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Archana Ashokan Jamien Wee Han Lim Nicholas Hang Rupshi Mitra Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
description	Abstract Prelimbic cortex and infralimbic cortex, parts of the ventromedial prefrontal cortex, are critical brain regions for generating a flexible behavioral response to changing environmental contingencies. This includes the role of these brain structures in the extinction of learned fear, decision making and retrieval of remote memories. Dendritic structure of medial prefrontal cortex neurons retains significant structural plasticity in adulthood. This has been mainly demonstrated as dendritic atrophy and loss of dendritic spines due to chronic stress. It remains unknown if housing condition of the animals itself can cause opposing changes in the dendritic organization. In that backdrop, here we report that short-term increase in complexity of the housing causes a robust increase in complexity of dendritic architecture of prelimbic and infralimbic neurons. This is reflected in the dendritic expansion of prelimbic neurons and increase in spine density of prelimbic and infralimbic neurons. These results suggest that non-invasive changes in the housing environment can be harnessed to study brain reserves for the flexible and species-typical behaviors.
format	article
author	Archana Ashokan Jamien Wee Han Lim Nicholas Hang Rupshi Mitra
author_facet	Archana Ashokan Jamien Wee Han Lim Nicholas Hang Rupshi Mitra
author_sort	Archana Ashokan
title	Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
title_short	Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
title_full	Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
title_fullStr	Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
title_full_unstemmed	Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
title_sort	complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e656e07222dd4fcbaf00a0c8d3523eb5
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_version_	1718388157910614016

Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons

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