Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence

Background: Alcohol dependence, a global public health problem, leads to structural and functional damage in the brain. Alcohol dependence patients present complex and varied clinical manifestations and live with general complaints existing in contemporary society, making most people with alcohol de...

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Autores principales:	Yanfei Li, Ranran Duan, Zhe Gong, Lijun Jing, Tian Zhang, Yong Zhang, Yanjie Jia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	NLRP3 NfL alcohol dependence biomarker white matter lesions gray matter volume Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/e65768aa679e46adbbb090e243e77dcb
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spelling	oai:doaj.org-article:e65768aa679e46adbbb090e243e77dcb2021-11-18T09:26:31ZNeurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence1664-064010.3389/fpsyt.2021.754969https://doaj.org/article/e65768aa679e46adbbb090e243e77dcb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.754969/fullhttps://doaj.org/toc/1664-0640Background: Alcohol dependence, a global public health problem, leads to structural and functional damage in the brain. Alcohol dependence patients present complex and varied clinical manifestations and live with general complaints existing in contemporary society, making most people with alcohol dependence hard to identify. Therefore, it is important to find potential biomarkers for the diagnosis and evaluation of alcohol dependence. In the study, we explored potential biomarkers for the diagnosis and monitoring of diseases and evaluated brain structural changes in alcohol dependence patients.Methods: Enzyme-linked immunosorbent assay (ELSA) was employed to detect the expression of serum nucleotide-binding oligomerization domain containing 3 (NLRP3) and single-molecule array (Simoa) assay was used to detect the expression of serum neurofilament light (NfL) in 50 alcohol dependence patients and 50 controls with no drinking history. Alcohol consumption was measured by standard drinks. Neuropsychological assessments, including the Montreal cognitive assessment (MoCA), Pittsburgh sleep quality index (PSQI), generalized anxiety disorder (GAD-7), and patient health questionnaire-9 (PHQ-9), were conducted to evaluate cognitive function and psychological state. The degree of white matter lesions (WMLs) was rated using the Fazekas scale based on magnetic resonance imaging analysis. White matter structure was quantified using the voxel-based morphometry method. The correlations between NLRP3 levels, NfL levels, neuropsychological dysfunction, the degree of WMLs, and white matter volume (WMV) were analyzed in alcohol dependence patients.Results: Serum NLRP3 and NfL levels were higher in the alcohol dependence group. NLRP3 levels were irrelevant to monthly alcohol assumption as well as to the MoCA, PSQI, GAD-7, PHQ-9, and Fazekas scale scores and WMV. NfL levels were positively correlated with the PSQI and PHQ-9 scores as well as the degree of WMLs and negatively correlated with the MoCA scores and WMV. No associations were evident between NfL and monthly alcohol assumption and GAD-7 scores in the alcohol dependence group.Conclusion: This study supports the potential value of serum NfL as a non-invasive biomarker in alcohol dependence. The association with neuropsychological dysfunction and degree of WMLs has implications to use NfL as a promising biomarker to assess the severity of brain damage as well as the progression and prognosis of alcohol dependence.Yanfei LiRanran DuanZhe GongLijun JingTian ZhangYong ZhangYanjie JiaFrontiers Media S.A.articleNLRP3NfLalcohol dependencebiomarkerwhite matter lesionsgray matter volumePsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NLRP3 NfL alcohol dependence biomarker white matter lesions gray matter volume Psychiatry RC435-571
spellingShingle	NLRP3 NfL alcohol dependence biomarker white matter lesions gray matter volume Psychiatry RC435-571 Yanfei Li Ranran Duan Zhe Gong Lijun Jing Tian Zhang Yong Zhang Yanjie Jia Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
description	Background: Alcohol dependence, a global public health problem, leads to structural and functional damage in the brain. Alcohol dependence patients present complex and varied clinical manifestations and live with general complaints existing in contemporary society, making most people with alcohol dependence hard to identify. Therefore, it is important to find potential biomarkers for the diagnosis and evaluation of alcohol dependence. In the study, we explored potential biomarkers for the diagnosis and monitoring of diseases and evaluated brain structural changes in alcohol dependence patients.Methods: Enzyme-linked immunosorbent assay (ELSA) was employed to detect the expression of serum nucleotide-binding oligomerization domain containing 3 (NLRP3) and single-molecule array (Simoa) assay was used to detect the expression of serum neurofilament light (NfL) in 50 alcohol dependence patients and 50 controls with no drinking history. Alcohol consumption was measured by standard drinks. Neuropsychological assessments, including the Montreal cognitive assessment (MoCA), Pittsburgh sleep quality index (PSQI), generalized anxiety disorder (GAD-7), and patient health questionnaire-9 (PHQ-9), were conducted to evaluate cognitive function and psychological state. The degree of white matter lesions (WMLs) was rated using the Fazekas scale based on magnetic resonance imaging analysis. White matter structure was quantified using the voxel-based morphometry method. The correlations between NLRP3 levels, NfL levels, neuropsychological dysfunction, the degree of WMLs, and white matter volume (WMV) were analyzed in alcohol dependence patients.Results: Serum NLRP3 and NfL levels were higher in the alcohol dependence group. NLRP3 levels were irrelevant to monthly alcohol assumption as well as to the MoCA, PSQI, GAD-7, PHQ-9, and Fazekas scale scores and WMV. NfL levels were positively correlated with the PSQI and PHQ-9 scores as well as the degree of WMLs and negatively correlated with the MoCA scores and WMV. No associations were evident between NfL and monthly alcohol assumption and GAD-7 scores in the alcohol dependence group.Conclusion: This study supports the potential value of serum NfL as a non-invasive biomarker in alcohol dependence. The association with neuropsychological dysfunction and degree of WMLs has implications to use NfL as a promising biomarker to assess the severity of brain damage as well as the progression and prognosis of alcohol dependence.
format	article
author	Yanfei Li Ranran Duan Zhe Gong Lijun Jing Tian Zhang Yong Zhang Yanjie Jia
author_facet	Yanfei Li Ranran Duan Zhe Gong Lijun Jing Tian Zhang Yong Zhang Yanjie Jia
author_sort	Yanfei Li
title	Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
title_short	Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
title_full	Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
title_fullStr	Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
title_full_unstemmed	Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
title_sort	neurofilament light chain is a promising biomarker in alcohol dependence
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e65768aa679e46adbbb090e243e77dcb
work_keys_str_mv	AT yanfeili neurofilamentlightchainisapromisingbiomarkerinalcoholdependence AT ranranduan neurofilamentlightchainisapromisingbiomarkerinalcoholdependence AT zhegong neurofilamentlightchainisapromisingbiomarkerinalcoholdependence AT lijunjing neurofilamentlightchainisapromisingbiomarkerinalcoholdependence AT tianzhang neurofilamentlightchainisapromisingbiomarkerinalcoholdependence AT yongzhang neurofilamentlightchainisapromisingbiomarkerinalcoholdependence AT yanjiejia neurofilamentlightchainisapromisingbiomarkerinalcoholdependence
_version_	1718420936827338752

Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence

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