Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal

Abstract Vertebrate sex differentiation follows a conserved suite of developmental events: the bipotential gonads differentiate and shortly thereafter sex specific traits become dimorphic. However, this may not apply to squamates, a diverse vertebrate lineage comprising of many species with thermose...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sarah L. Whiteley, Vera Weisbecker, Arthur Georges, Arnault Roger Gaston Gauthier, Darryl L. Whitehead, Clare E. Holleley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Vitticeps Ovotestis Gonadal Differentiation Niveoscincus Ocellatus Sexual Development Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e65ca5deff1b47358486fb2b800c289e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e65ca5deff1b47358486fb2b800c289e
record_format	dspace
spelling	oai:doaj.org-article:e65ca5deff1b47358486fb2b800c289e2021-12-02T11:40:54ZDevelopmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal10.1038/s41598-018-33170-y2045-2322https://doaj.org/article/e65ca5deff1b47358486fb2b800c289e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33170-yhttps://doaj.org/toc/2045-2322Abstract Vertebrate sex differentiation follows a conserved suite of developmental events: the bipotential gonads differentiate and shortly thereafter sex specific traits become dimorphic. However, this may not apply to squamates, a diverse vertebrate lineage comprising of many species with thermosensitive sexual development. Of the three species with data on the relative timing of gonad differentiation and genital dimorphism, the females of two (Niveoscincus ocellatus and Barisia imbricata) exhibit a phase of temporary pseudohermaphroditism or TPH (gonads have differentiated well before genital dimorphism). We report a third example of TPH in Pogona vitticeps, an agamid with temperature-induced male to female sex reversal. These findings suggest that for female squamates, genital and gonad development may not be closely synchronised, so that TPH may be common. We further observed a high frequency of ovotestes, a usually rare gonadal phenotype characterised by a mix of male and female structures, exclusively associated with temperature-induced sex reversal. We propose that ovotestes are evidence of a period of antagonism between male and female sex-determining pathways during sex reversal. Female sexual development in squamates is considerably more complex than has been appreciated, providing numerous avenues for future exploration of the genetic and hormonal cues that govern sexual development.Sarah L. WhiteleyVera WeisbeckerArthur GeorgesArnault Roger Gaston GauthierDarryl L. WhiteheadClare E. HolleleyNature PortfolioarticleVitticepsOvotestisGonadal DifferentiationNiveoscincus OcellatusSexual DevelopmentMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitticeps Ovotestis Gonadal Differentiation Niveoscincus Ocellatus Sexual Development Medicine R Science Q
spellingShingle	Vitticeps Ovotestis Gonadal Differentiation Niveoscincus Ocellatus Sexual Development Medicine R Science Q Sarah L. Whiteley Vera Weisbecker Arthur Georges Arnault Roger Gaston Gauthier Darryl L. Whitehead Clare E. Holleley Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
description	Abstract Vertebrate sex differentiation follows a conserved suite of developmental events: the bipotential gonads differentiate and shortly thereafter sex specific traits become dimorphic. However, this may not apply to squamates, a diverse vertebrate lineage comprising of many species with thermosensitive sexual development. Of the three species with data on the relative timing of gonad differentiation and genital dimorphism, the females of two (Niveoscincus ocellatus and Barisia imbricata) exhibit a phase of temporary pseudohermaphroditism or TPH (gonads have differentiated well before genital dimorphism). We report a third example of TPH in Pogona vitticeps, an agamid with temperature-induced male to female sex reversal. These findings suggest that for female squamates, genital and gonad development may not be closely synchronised, so that TPH may be common. We further observed a high frequency of ovotestes, a usually rare gonadal phenotype characterised by a mix of male and female structures, exclusively associated with temperature-induced sex reversal. We propose that ovotestes are evidence of a period of antagonism between male and female sex-determining pathways during sex reversal. Female sexual development in squamates is considerably more complex than has been appreciated, providing numerous avenues for future exploration of the genetic and hormonal cues that govern sexual development.
format	article
author	Sarah L. Whiteley Vera Weisbecker Arthur Georges Arnault Roger Gaston Gauthier Darryl L. Whitehead Clare E. Holleley
author_facet	Sarah L. Whiteley Vera Weisbecker Arthur Georges Arnault Roger Gaston Gauthier Darryl L. Whitehead Clare E. Holleley
author_sort	Sarah L. Whiteley
title	Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
title_short	Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
title_full	Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
title_fullStr	Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
title_full_unstemmed	Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
title_sort	developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e65ca5deff1b47358486fb2b800c289e
work_keys_str_mv	AT sarahlwhiteley developmentalasynchronyandantagonismofsexdeterminationpathwaysinalizardwithtemperatureinducedsexreversal AT veraweisbecker developmentalasynchronyandantagonismofsexdeterminationpathwaysinalizardwithtemperatureinducedsexreversal AT arthurgeorges developmentalasynchronyandantagonismofsexdeterminationpathwaysinalizardwithtemperatureinducedsexreversal AT arnaultrogergastongauthier developmentalasynchronyandantagonismofsexdeterminationpathwaysinalizardwithtemperatureinducedsexreversal AT darryllwhitehead developmentalasynchronyandantagonismofsexdeterminationpathwaysinalizardwithtemperatureinducedsexreversal AT clareeholleley developmentalasynchronyandantagonismofsexdeterminationpathwaysinalizardwithtemperatureinducedsexreversal
_version_	1718395554299379712

Developmental asynchrony and antagonism of sex determination pathways in a lizard with temperature-induced sex reversal

Ejemplares similares