Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

Abstract Otitis Media (OM) is characterized by epithelial abnormalities and defects in innate immunity in the middle ear (ME). Although, BPIFA1, a member of the BPI fold containing family of putative innate defence proteins is abundantly expressed by the ME epithelium and SNPs in Bpifa1 have been as...

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Autores principales:	Apoorva Mulay, Derek W. Hood, Debbie Williams, Catherine Russell, Steve D. M. Brown, Lynne Bingle, Michael Cheeseman, Colin D. Bingle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e65ef82b32dd466f8b1795d40269554f
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spelling	oai:doaj.org-article:e65ef82b32dd466f8b1795d40269554f2021-12-02T15:08:18ZLoss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model10.1038/s41598-018-21166-72045-2322https://doaj.org/article/e65ef82b32dd466f8b1795d40269554f2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21166-7https://doaj.org/toc/2045-2322Abstract Otitis Media (OM) is characterized by epithelial abnormalities and defects in innate immunity in the middle ear (ME). Although, BPIFA1, a member of the BPI fold containing family of putative innate defence proteins is abundantly expressed by the ME epithelium and SNPs in Bpifa1 have been associated with OM susceptibility, its role in the ME is not well characterized. We investigated the role of BPIFA1 in protection of the ME and the development of OM using murine models. Loss of Bpifa1 did not lead to OM development. However, deletion of Bpifa1 in Evi1 Jbo/+ mice, a model of chronic OM, caused significant exacerbation of OM severity, thickening of the ME mucosa and increased collagen deposition, without a significant increase in pro-inflammatory gene expression. Our data suggests that BPIFA1 is involved in maintaining homeostasis within the ME under steady state conditions and its loss in the presence of inflammation, exacerbates epithelial remodelling leading to more severe OM.Apoorva MulayDerek W. HoodDebbie WilliamsCatherine RussellSteve D. M. BrownLynne BingleMichael CheesemanColin D. BingleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Apoorva Mulay Derek W. Hood Debbie Williams Catherine Russell Steve D. M. Brown Lynne Bingle Michael Cheeseman Colin D. Bingle Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model
description	Abstract Otitis Media (OM) is characterized by epithelial abnormalities and defects in innate immunity in the middle ear (ME). Although, BPIFA1, a member of the BPI fold containing family of putative innate defence proteins is abundantly expressed by the ME epithelium and SNPs in Bpifa1 have been associated with OM susceptibility, its role in the ME is not well characterized. We investigated the role of BPIFA1 in protection of the ME and the development of OM using murine models. Loss of Bpifa1 did not lead to OM development. However, deletion of Bpifa1 in Evi1 Jbo/+ mice, a model of chronic OM, caused significant exacerbation of OM severity, thickening of the ME mucosa and increased collagen deposition, without a significant increase in pro-inflammatory gene expression. Our data suggests that BPIFA1 is involved in maintaining homeostasis within the ME under steady state conditions and its loss in the presence of inflammation, exacerbates epithelial remodelling leading to more severe OM.
format	article
author	Apoorva Mulay Derek W. Hood Debbie Williams Catherine Russell Steve D. M. Brown Lynne Bingle Michael Cheeseman Colin D. Bingle
author_facet	Apoorva Mulay Derek W. Hood Debbie Williams Catherine Russell Steve D. M. Brown Lynne Bingle Michael Cheeseman Colin D. Bingle
author_sort	Apoorva Mulay
title	Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model
title_short	Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model
title_full	Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model
title_fullStr	Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model
title_full_unstemmed	Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model
title_sort	loss of the homeostatic protein bpifa1, leads to exacerbation of otitis media severity in the junbo mouse model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e65ef82b32dd466f8b1795d40269554f
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Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

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