Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span

Abstract Adaptation to metabolic challenges is an individual process in animals and human, most likely based on genetic background. To identify novel pathways of importance for individual adaptation to a metabolic challenge such as egg production in laying hens, myo-inositol (MI) metabolism and plas...

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Autores principales:	Fernando Gonzalez-Uarquin, Vera Sommerfeld, Markus Rodehutscord, Korinna Huber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e66195f967304847a42db965c8bbb949
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spelling	oai:doaj.org-article:e66195f967304847a42db965c8bbb9492021-12-02T13:34:58ZInterrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span10.1038/s41598-021-84169-x2045-2322https://doaj.org/article/e66195f967304847a42db965c8bbb9492021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84169-xhttps://doaj.org/toc/2045-2322Abstract Adaptation to metabolic challenges is an individual process in animals and human, most likely based on genetic background. To identify novel pathways of importance for individual adaptation to a metabolic challenge such as egg production in laying hens, myo-inositol (MI) metabolism and plasma metabolite profiles during the productive lifespan were examined in two genetically different strains, Lohmann Brown-Classic (LB) and LSL-Classic (LSL) hens. They were housed during the productive lifespan and sampled at 10, 16, 24, 30 and 60 weeks of age. The targeted AbsoluteIDQ p180 Kit was used for metabolite profiling in plasma whereas a MI enzymatic kit and ELISAs were used to quantify tissue MI concentrations and MI key enzymes (IMPase 1 and MIOX), respectively. As major finding, kidney MIOX was differently expressed in LB and LSL hens with higher amounts in LB. The onset of egg laying between week 16 and 24 of life span was associated with a clear change in the metabolite profiles, however LSL hens and LB hens adapt differently. Pearson’s correlation analyses over all hens at all time points indicated that higher expression of MI degrading enzyme MIOX was related to markers indicating metabolic stress.Fernando Gonzalez-UarquinVera SommerfeldMarkus RodehutscordKorinna HuberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fernando Gonzalez-Uarquin Vera Sommerfeld Markus Rodehutscord Korinna Huber Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
description	Abstract Adaptation to metabolic challenges is an individual process in animals and human, most likely based on genetic background. To identify novel pathways of importance for individual adaptation to a metabolic challenge such as egg production in laying hens, myo-inositol (MI) metabolism and plasma metabolite profiles during the productive lifespan were examined in two genetically different strains, Lohmann Brown-Classic (LB) and LSL-Classic (LSL) hens. They were housed during the productive lifespan and sampled at 10, 16, 24, 30 and 60 weeks of age. The targeted AbsoluteIDQ p180 Kit was used for metabolite profiling in plasma whereas a MI enzymatic kit and ELISAs were used to quantify tissue MI concentrations and MI key enzymes (IMPase 1 and MIOX), respectively. As major finding, kidney MIOX was differently expressed in LB and LSL hens with higher amounts in LB. The onset of egg laying between week 16 and 24 of life span was associated with a clear change in the metabolite profiles, however LSL hens and LB hens adapt differently. Pearson’s correlation analyses over all hens at all time points indicated that higher expression of MI degrading enzyme MIOX was related to markers indicating metabolic stress.
format	article
author	Fernando Gonzalez-Uarquin Vera Sommerfeld Markus Rodehutscord Korinna Huber
author_facet	Fernando Gonzalez-Uarquin Vera Sommerfeld Markus Rodehutscord Korinna Huber
author_sort	Fernando Gonzalez-Uarquin
title	Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
title_short	Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
title_full	Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
title_fullStr	Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
title_full_unstemmed	Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
title_sort	interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e66195f967304847a42db965c8bbb949
work_keys_str_mv	AT fernandogonzalezuarquin interrelationshipofmyoinositolpathwayswithsystemicmetabolicconditionsintwostrainsofhighperformancelayinghensduringtheirproductivelifespan AT verasommerfeld interrelationshipofmyoinositolpathwayswithsystemicmetabolicconditionsintwostrainsofhighperformancelayinghensduringtheirproductivelifespan AT markusrodehutscord interrelationshipofmyoinositolpathwayswithsystemicmetabolicconditionsintwostrainsofhighperformancelayinghensduringtheirproductivelifespan AT korinnahuber interrelationshipofmyoinositolpathwayswithsystemicmetabolicconditionsintwostrainsofhighperformancelayinghensduringtheirproductivelifespan
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Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span

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