Triacylglycerol synthesis enhances macrophage inflammatory function

As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent...

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Autores principales:	Angela Castoldi, Lauar B. Monteiro, Nikki van Teijlingen Bakker, David E. Sanin, Nisha Rana, Mauro Corrado, Alanna M. Cameron, Fabian Hässler, Mai Matsushita, George Caputa, Ramon I. Klein Geltink, Jörg Büscher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e66368483cc344ee9854c2ede5bf41d5
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spelling	oai:doaj.org-article:e66368483cc344ee9854c2ede5bf41d52021-12-02T18:50:45ZTriacylglycerol synthesis enhances macrophage inflammatory function10.1038/s41467-020-17881-32041-1723https://doaj.org/article/e66368483cc344ee9854c2ede5bf41d52020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17881-3https://doaj.org/toc/2041-1723As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent inflammatory activation.Angela CastoldiLauar B. MonteiroNikki van Teijlingen BakkerDavid E. SaninNisha RanaMauro CorradoAlanna M. CameronFabian HässlerMai MatsushitaGeorge CaputaRamon I. Klein GeltinkJörg BüscherJoy Edwards-HicksErika L. PearceEdward J. PearceNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angela Castoldi Lauar B. Monteiro Nikki van Teijlingen Bakker David E. Sanin Nisha Rana Mauro Corrado Alanna M. Cameron Fabian Hässler Mai Matsushita George Caputa Ramon I. Klein Geltink Jörg Büscher Joy Edwards-Hicks Erika L. Pearce Edward J. Pearce Triacylglycerol synthesis enhances macrophage inflammatory function
description	As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent inflammatory activation.
format	article
author	Angela Castoldi Lauar B. Monteiro Nikki van Teijlingen Bakker David E. Sanin Nisha Rana Mauro Corrado Alanna M. Cameron Fabian Hässler Mai Matsushita George Caputa Ramon I. Klein Geltink Jörg Büscher Joy Edwards-Hicks Erika L. Pearce Edward J. Pearce
author_facet	Angela Castoldi Lauar B. Monteiro Nikki van Teijlingen Bakker David E. Sanin Nisha Rana Mauro Corrado Alanna M. Cameron Fabian Hässler Mai Matsushita George Caputa Ramon I. Klein Geltink Jörg Büscher Joy Edwards-Hicks Erika L. Pearce Edward J. Pearce
author_sort	Angela Castoldi
title	Triacylglycerol synthesis enhances macrophage inflammatory function
title_short	Triacylglycerol synthesis enhances macrophage inflammatory function
title_full	Triacylglycerol synthesis enhances macrophage inflammatory function
title_fullStr	Triacylglycerol synthesis enhances macrophage inflammatory function
title_full_unstemmed	Triacylglycerol synthesis enhances macrophage inflammatory function
title_sort	triacylglycerol synthesis enhances macrophage inflammatory function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e66368483cc344ee9854c2ede5bf41d5
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Triacylglycerol synthesis enhances macrophage inflammatory function

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