Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.

The last years of research have proposed that bacteria might be involved in and contribute to the lack of healing of chronic wounds. Especially it seems that Pseudomonas aeruginosa play a crucial role in the healing. At Copenhagen Wound Healing Centre it was for many years clinical suspected that on...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Trine Høgsberg, Thomas Bjarnsholt, Jens Schiersing Thomsen, Klaus Kirketerp-Møller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e665bedc8ade482eb664baac699d2406
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e665bedc8ade482eb664baac699d2406
record_format	dspace
spelling	oai:doaj.org-article:e665bedc8ade482eb664baac699d24062021-11-18T06:52:50ZSuccess rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.1932-620310.1371/journal.pone.0020492https://doaj.org/article/e665bedc8ade482eb664baac699d24062011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655269/?tool=EBIhttps://doaj.org/toc/1932-6203The last years of research have proposed that bacteria might be involved in and contribute to the lack of healing of chronic wounds. Especially it seems that Pseudomonas aeruginosa play a crucial role in the healing. At Copenhagen Wound Healing Centre it was for many years clinical suspected that once chronic venous leg ulcers were colonized (weeks or months preoperatively) by P. aeruginosa, the success rate of skin grafting deteriorated despite aggressive treatment. To investigate this, a retrospective study was performed on the clinical outcome of 82 consecutive patients with chronic venous leg ulcers on 91 extremities, from the 1(st) of March 2005 until the 31(st) of August 2006. This was achieved by analysing the microbiology, demographic data, smoking and drinking habits, diabetes, renal impairment, co-morbidities, approximated size and age of the wounds, immunosuppressive treatment and complicating factors on the clinical outcome of each patient. The results were evaluated using a Student T-test for continuous parameters, chi-square test for categorical parameters and a logistic regression analysis to predict healing after 12 weeks. The analysis revealed that only 33,3% of ulcers with P. aeruginosa, isolated at least once from 12 weeks prior, to or during surgery, were healed (98% or more) by week 12 follow-up, while 73,1% of ulcers without P. aeruginosa were so by the same time (p = 0.001). Smoking also significantly suppressed the outcome at the 12-week follow-up. Subsequently, a logistic regression analysis was carried out leaving P. aeruginosa as the only predictor left in the model (p = 0.001). This study supports our hypothesis that P. aeruginosa in chronic venous leg ulcers, despite treatment, has considerable impact on partial take or rejection of split-thickness skin grafts.Trine HøgsbergThomas BjarnsholtJens Schiersing ThomsenKlaus Kirketerp-MøllerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20492 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Trine Høgsberg Thomas Bjarnsholt Jens Schiersing Thomsen Klaus Kirketerp-Møller Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.
description	The last years of research have proposed that bacteria might be involved in and contribute to the lack of healing of chronic wounds. Especially it seems that Pseudomonas aeruginosa play a crucial role in the healing. At Copenhagen Wound Healing Centre it was for many years clinical suspected that once chronic venous leg ulcers were colonized (weeks or months preoperatively) by P. aeruginosa, the success rate of skin grafting deteriorated despite aggressive treatment. To investigate this, a retrospective study was performed on the clinical outcome of 82 consecutive patients with chronic venous leg ulcers on 91 extremities, from the 1(st) of March 2005 until the 31(st) of August 2006. This was achieved by analysing the microbiology, demographic data, smoking and drinking habits, diabetes, renal impairment, co-morbidities, approximated size and age of the wounds, immunosuppressive treatment and complicating factors on the clinical outcome of each patient. The results were evaluated using a Student T-test for continuous parameters, chi-square test for categorical parameters and a logistic regression analysis to predict healing after 12 weeks. The analysis revealed that only 33,3% of ulcers with P. aeruginosa, isolated at least once from 12 weeks prior, to or during surgery, were healed (98% or more) by week 12 follow-up, while 73,1% of ulcers without P. aeruginosa were so by the same time (p = 0.001). Smoking also significantly suppressed the outcome at the 12-week follow-up. Subsequently, a logistic regression analysis was carried out leaving P. aeruginosa as the only predictor left in the model (p = 0.001). This study supports our hypothesis that P. aeruginosa in chronic venous leg ulcers, despite treatment, has considerable impact on partial take or rejection of split-thickness skin grafts.
format	article
author	Trine Høgsberg Thomas Bjarnsholt Jens Schiersing Thomsen Klaus Kirketerp-Møller
author_facet	Trine Høgsberg Thomas Bjarnsholt Jens Schiersing Thomsen Klaus Kirketerp-Møller
author_sort	Trine Høgsberg
title	Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.
title_short	Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.
title_full	Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.
title_fullStr	Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.
title_full_unstemmed	Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.
title_sort	success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of pseudomonas aeruginosa: a retrospective study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e665bedc8ade482eb664baac699d2406
work_keys_str_mv	AT trinehøgsberg successrateofsplitthicknessskingraftingofchronicvenouslegulcersdependsonthepresenceofpseudomonasaeruginosaaretrospectivestudy AT thomasbjarnsholt successrateofsplitthicknessskingraftingofchronicvenouslegulcersdependsonthepresenceofpseudomonasaeruginosaaretrospectivestudy AT jensschiersingthomsen successrateofsplitthicknessskingraftingofchronicvenouslegulcersdependsonthepresenceofpseudomonasaeruginosaaretrospectivestudy AT klauskirketerpmøller successrateofsplitthicknessskingraftingofchronicvenouslegulcersdependsonthepresenceofpseudomonasaeruginosaaretrospectivestudy
_version_	1718424262446940160

Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.

Ejemplares similares