Biosynthesis of fragin is controlled by a novel quorum sensing signal

Fragin is a diazeniumdiolate metabolite with antifungal activity, produced by some bacteria. Here, Jenul et al. show that metal chelation is the molecular basis of fragin’s antifungal activity, and that a gene cluster directing fragin biosynthesis is also involved in the synthesis of a signal molecu...

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Autores principales:	Christian Jenul, Simon Sieber, Christophe Daeppen, Anugraha Mathew, Martina Lardi, Gabriella Pessi, Dominic Hoepfner, Markus Neuburger, Anthony Linden, Karl Gademann, Leo Eberl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e667f4b8d5a8496998a5b838679cb854
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spelling	oai:doaj.org-article:e667f4b8d5a8496998a5b838679cb8542021-12-02T15:34:06ZBiosynthesis of fragin is controlled by a novel quorum sensing signal10.1038/s41467-018-03690-22041-1723https://doaj.org/article/e667f4b8d5a8496998a5b838679cb8542018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03690-2https://doaj.org/toc/2041-1723Fragin is a diazeniumdiolate metabolite with antifungal activity, produced by some bacteria. Here, Jenul et al. show that metal chelation is the molecular basis of fragin’s antifungal activity, and that a gene cluster directing fragin biosynthesis is also involved in the synthesis of a signal molecule.Christian JenulSimon SieberChristophe DaeppenAnugraha MathewMartina LardiGabriella PessiDominic HoepfnerMarkus NeuburgerAnthony LindenKarl GademannLeo EberlNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Jenul Simon Sieber Christophe Daeppen Anugraha Mathew Martina Lardi Gabriella Pessi Dominic Hoepfner Markus Neuburger Anthony Linden Karl Gademann Leo Eberl Biosynthesis of fragin is controlled by a novel quorum sensing signal
description	Fragin is a diazeniumdiolate metabolite with antifungal activity, produced by some bacteria. Here, Jenul et al. show that metal chelation is the molecular basis of fragin’s antifungal activity, and that a gene cluster directing fragin biosynthesis is also involved in the synthesis of a signal molecule.
format	article
author	Christian Jenul Simon Sieber Christophe Daeppen Anugraha Mathew Martina Lardi Gabriella Pessi Dominic Hoepfner Markus Neuburger Anthony Linden Karl Gademann Leo Eberl
author_facet	Christian Jenul Simon Sieber Christophe Daeppen Anugraha Mathew Martina Lardi Gabriella Pessi Dominic Hoepfner Markus Neuburger Anthony Linden Karl Gademann Leo Eberl
author_sort	Christian Jenul
title	Biosynthesis of fragin is controlled by a novel quorum sensing signal
title_short	Biosynthesis of fragin is controlled by a novel quorum sensing signal
title_full	Biosynthesis of fragin is controlled by a novel quorum sensing signal
title_fullStr	Biosynthesis of fragin is controlled by a novel quorum sensing signal
title_full_unstemmed	Biosynthesis of fragin is controlled by a novel quorum sensing signal
title_sort	biosynthesis of fragin is controlled by a novel quorum sensing signal
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e667f4b8d5a8496998a5b838679cb854
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Biosynthesis of fragin is controlled by a novel quorum sensing signal

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