Targeting Gα13-integrin interaction ameliorates systemic inflammation

Bacterial or viral infection can lead to lethal systemic inflammation and thrombosis. Here, the authors show that inhibiting integrin outside-in signaling in leukocytes and platelets alleviates inflammation/clotting and improved survival in septic mice.

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Autores principales:	Ni Cheng, Yaping Zhang, M. Keegan Delaney, Can Wang, Yanyan Bai, Randal A. Skidgel, Xiaoping Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e66b023a568544b382044f96963b1696
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spelling	oai:doaj.org-article:e66b023a568544b382044f96963b16962021-12-02T14:49:22ZTargeting Gα13-integrin interaction ameliorates systemic inflammation10.1038/s41467-021-23409-02041-1723https://doaj.org/article/e66b023a568544b382044f96963b16962021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23409-0https://doaj.org/toc/2041-1723Bacterial or viral infection can lead to lethal systemic inflammation and thrombosis. Here, the authors show that inhibiting integrin outside-in signaling in leukocytes and platelets alleviates inflammation/clotting and improved survival in septic mice.Ni ChengYaping ZhangM. Keegan DelaneyCan WangYanyan BaiRandal A. SkidgelXiaoping DuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ni Cheng Yaping Zhang M. Keegan Delaney Can Wang Yanyan Bai Randal A. Skidgel Xiaoping Du Targeting Gα13-integrin interaction ameliorates systemic inflammation
description	Bacterial or viral infection can lead to lethal systemic inflammation and thrombosis. Here, the authors show that inhibiting integrin outside-in signaling in leukocytes and platelets alleviates inflammation/clotting and improved survival in septic mice.
format	article
author	Ni Cheng Yaping Zhang M. Keegan Delaney Can Wang Yanyan Bai Randal A. Skidgel Xiaoping Du
author_facet	Ni Cheng Yaping Zhang M. Keegan Delaney Can Wang Yanyan Bai Randal A. Skidgel Xiaoping Du
author_sort	Ni Cheng
title	Targeting Gα13-integrin interaction ameliorates systemic inflammation
title_short	Targeting Gα13-integrin interaction ameliorates systemic inflammation
title_full	Targeting Gα13-integrin interaction ameliorates systemic inflammation
title_fullStr	Targeting Gα13-integrin interaction ameliorates systemic inflammation
title_full_unstemmed	Targeting Gα13-integrin interaction ameliorates systemic inflammation
title_sort	targeting gα13-integrin interaction ameliorates systemic inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e66b023a568544b382044f96963b1696
work_keys_str_mv	AT nicheng targetingga13integrininteractionamelioratessystemicinflammation AT yapingzhang targetingga13integrininteractionamelioratessystemicinflammation AT mkeegandelaney targetingga13integrininteractionamelioratessystemicinflammation AT canwang targetingga13integrininteractionamelioratessystemicinflammation AT yanyanbai targetingga13integrininteractionamelioratessystemicinflammation AT randalaskidgel targetingga13integrininteractionamelioratessystemicinflammation AT xiaopingdu targetingga13integrininteractionamelioratessystemicinflammation
_version_	1718389539909664768

Targeting Gα13-integrin interaction ameliorates systemic inflammation

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