Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Zinc finger nucleases have an established role in genome editing. Here, the authors report a strategy for identifying zinc finger nucleases that discriminate between desired targets and provide genome-wide specificity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Benjamin L. Oakes, Danny F. Xia, Elizabeth F. Rowland, Denise J. Xu, Irina Ankoudinova, Jennifer S. Borchardt, Lei Zhang, Patrick Li, Jeffrey C. Miller, Edward J. Rebar, Marcus B. Noyes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e66bba0eeef149b0809ce032052bdf58
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e66bba0eeef149b0809ce032052bdf58
record_format	dspace
spelling	oai:doaj.org-article:e66bba0eeef149b0809ce032052bdf582021-12-02T14:39:34ZMulti-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing10.1038/ncomms101942041-1723https://doaj.org/article/e66bba0eeef149b0809ce032052bdf582016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10194https://doaj.org/toc/2041-1723Zinc finger nucleases have an established role in genome editing. Here, the authors report a strategy for identifying zinc finger nucleases that discriminate between desired targets and provide genome-wide specificity.Benjamin L. OakesDanny F. XiaElizabeth F. RowlandDenise J. XuIrina AnkoudinovaJennifer S. BorchardtLei ZhangPatrick LiJeffrey C. MillerEdward J. RebarMarcus B. NoyesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin L. Oakes Danny F. Xia Elizabeth F. Rowland Denise J. Xu Irina Ankoudinova Jennifer S. Borchardt Lei Zhang Patrick Li Jeffrey C. Miller Edward J. Rebar Marcus B. Noyes Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
description	Zinc finger nucleases have an established role in genome editing. Here, the authors report a strategy for identifying zinc finger nucleases that discriminate between desired targets and provide genome-wide specificity.
format	article
author	Benjamin L. Oakes Danny F. Xia Elizabeth F. Rowland Denise J. Xu Irina Ankoudinova Jennifer S. Borchardt Lei Zhang Patrick Li Jeffrey C. Miller Edward J. Rebar Marcus B. Noyes
author_facet	Benjamin L. Oakes Danny F. Xia Elizabeth F. Rowland Denise J. Xu Irina Ankoudinova Jennifer S. Borchardt Lei Zhang Patrick Li Jeffrey C. Miller Edward J. Rebar Marcus B. Noyes
author_sort	Benjamin L. Oakes
title	Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
title_short	Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
title_full	Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
title_fullStr	Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
title_full_unstemmed	Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
title_sort	multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e66bba0eeef149b0809ce032052bdf58
work_keys_str_mv	AT benjaminloakes multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT dannyfxia multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT elizabethfrowland multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT denisejxu multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT irinaankoudinova multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT jennifersborchardt multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT leizhang multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT patrickli multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT jeffreycmiller multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT edwardjrebar multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting AT marcusbnoyes multireporterselectionforthedesignofactiveandmorespecificzincfingernucleasesforgenomeediting
_version_	1718390625919827968

Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Ejemplares similares