Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model
Abstract Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystrophin. This lack also affects cardiac structure and function, and cardiovascular complications are a major cause of death in DMD. Newly developed therapies partially restore dystrophin expressio...
Enregistré dans:
Auteurs principaux: | Gerard A. Marchal, Maaike van Putten, Arie O. Verkerk, Simona Casini, Kayleigh Putker, Shirley C. M. van Amersfoorth, Annemieke Aartsma-Rus, Elisabeth M. Lodder, Carol Ann Remme |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/e66d62ff25c047aab32a8e28fe2c4a19 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Author Correction: Timing and localization of human dystrophin isoform expression provide insights into the cognitive phenotype of Duchenne muscular dystrophy
par: Nathalie Doorenweerd, et autres
Publié: (2018) -
Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.
par: Thibaut Larcher, et autres
Publié: (2014) -
In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
par: Leonela Amoasii, et autres
Publié: (2019) -
A sensitive, reproducible and objective immunofluorescence analysis method of dystrophin in individual fibers in samples from patients with duchenne muscular dystrophy.
par: Chantal Beekman, et autres
Publié: (2014) -
Engraftment of human induced pluripotent stem cell-derived myogenic progenitors restores dystrophin in mice with duchenne muscular dystrophy
par: He,Ruojie, et autres
Publié: (2020)