Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with H3mm7 promoting open chromatin around promoters.

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Autores principales:	Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka, Yasuyuki Ohkawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e66f3e9bdb7d4d70baf9212e7ac7ae5e
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spelling	oai:doaj.org-article:e66f3e9bdb7d4d70baf9212e7ac7ae5e2021-12-02T15:33:33ZHistone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration10.1038/s41467-018-03845-12041-1723https://doaj.org/article/e66f3e9bdb7d4d70baf9212e7ac7ae5e2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03845-1https://doaj.org/toc/2041-1723Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with H3mm7 promoting open chromatin around promoters.Akihito HaradaKazumitsu MaeharaYusuke OnoHiroyuki TaguchiKiyoshi YoshiokaYasuo KitajimaYan XieYuko SatoTakeshi IwasakiJumpei NogamiSeiji OkadaTetsuro KomatsuYuichiro SembaTatsuya TakemotoHiroshi KimuraHitoshi KurumizakaYasuyuki OhkawaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akihito Harada Kazumitsu Maehara Yusuke Ono Hiroyuki Taguchi Kiyoshi Yoshioka Yasuo Kitajima Yan Xie Yuko Sato Takeshi Iwasaki Jumpei Nogami Seiji Okada Tetsuro Komatsu Yuichiro Semba Tatsuya Takemoto Hiroshi Kimura Hitoshi Kurumizaka Yasuyuki Ohkawa Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
description	Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with H3mm7 promoting open chromatin around promoters.
format	article
author	Akihito Harada Kazumitsu Maehara Yusuke Ono Hiroyuki Taguchi Kiyoshi Yoshioka Yasuo Kitajima Yan Xie Yuko Sato Takeshi Iwasaki Jumpei Nogami Seiji Okada Tetsuro Komatsu Yuichiro Semba Tatsuya Takemoto Hiroshi Kimura Hitoshi Kurumizaka Yasuyuki Ohkawa
author_facet	Akihito Harada Kazumitsu Maehara Yusuke Ono Hiroyuki Taguchi Kiyoshi Yoshioka Yasuo Kitajima Yan Xie Yuko Sato Takeshi Iwasaki Jumpei Nogami Seiji Okada Tetsuro Komatsu Yuichiro Semba Tatsuya Takemoto Hiroshi Kimura Hitoshi Kurumizaka Yasuyuki Ohkawa
author_sort	Akihito Harada
title	Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
title_short	Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
title_full	Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
title_fullStr	Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
title_full_unstemmed	Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
title_sort	histone h3.3 sub-variant h3mm7 is required for normal skeletal muscle regeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e66f3e9bdb7d4d70baf9212e7ac7ae5e
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Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

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