Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T lymphoblastic leukemia (T-ALL) identified in 2009, due to its unique immunophenotypic and genomic profile. The outcome of patients was poor in earlier studies, and they were prone to have induction failure, with...

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Autores principales:	Chun-fung Sin, Pui-hei Marcus Man
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ETP-ALL T lymphoblastic leukemia early T-cell precursor acute lymphoblastic leukemia diagnosis molecular pathogenesis novel therapies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e6709299e1584832bc967422cf3e0cc3
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id	oai:doaj.org-article:e6709299e1584832bc967422cf3e0cc3
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spelling	oai:doaj.org-article:e6709299e1584832bc967422cf3e0cc32021-12-01T12:27:08ZEarly T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies2234-943X10.3389/fonc.2021.750789https://doaj.org/article/e6709299e1584832bc967422cf3e0cc32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.750789/fullhttps://doaj.org/toc/2234-943XEarly T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T lymphoblastic leukemia (T-ALL) identified in 2009, due to its unique immunophenotypic and genomic profile. The outcome of patients was poor in earlier studies, and they were prone to have induction failure, with more frequent relapse/refractory disease. Recent advances had been made in discoveries of genetic aberrations and molecular pathogenesis of ETP-ALL. However, the diagnosis and management of ETP-ALL is still challenging. There are limited choices of novel therapies so far. In this review article, it highlighted the diagnostic issue of ETP-ALL, pitfall in diagnosis, and strategy of accurate diagnosis. The review also summarized current understanding of molecular mechanism of leukemogenesis. The emerging role of risk-adapted therapy and allogenic stem cell transplant in optimizing the outcome of patients with ETP-ALL was discussed. Finally, some potential novel therapies were proposed based on the current understanding of molecular pathogenesis.Chun-fung SinPui-hei Marcus ManFrontiers Media S.A.articleETP-ALLT lymphoblastic leukemiaearly T-cell precursor acute lymphoblastic leukemiadiagnosismolecular pathogenesisnovel therapiesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ETP-ALL T lymphoblastic leukemia early T-cell precursor acute lymphoblastic leukemia diagnosis molecular pathogenesis novel therapies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ETP-ALL T lymphoblastic leukemia early T-cell precursor acute lymphoblastic leukemia diagnosis molecular pathogenesis novel therapies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chun-fung Sin Pui-hei Marcus Man Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies
description	Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T lymphoblastic leukemia (T-ALL) identified in 2009, due to its unique immunophenotypic and genomic profile. The outcome of patients was poor in earlier studies, and they were prone to have induction failure, with more frequent relapse/refractory disease. Recent advances had been made in discoveries of genetic aberrations and molecular pathogenesis of ETP-ALL. However, the diagnosis and management of ETP-ALL is still challenging. There are limited choices of novel therapies so far. In this review article, it highlighted the diagnostic issue of ETP-ALL, pitfall in diagnosis, and strategy of accurate diagnosis. The review also summarized current understanding of molecular mechanism of leukemogenesis. The emerging role of risk-adapted therapy and allogenic stem cell transplant in optimizing the outcome of patients with ETP-ALL was discussed. Finally, some potential novel therapies were proposed based on the current understanding of molecular pathogenesis.
format	article
author	Chun-fung Sin Pui-hei Marcus Man
author_facet	Chun-fung Sin Pui-hei Marcus Man
author_sort	Chun-fung Sin
title	Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies
title_short	Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies
title_full	Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies
title_fullStr	Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies
title_full_unstemmed	Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies
title_sort	early t-cell precursor acute lymphoblastic leukemia: diagnosis, updates in molecular pathogenesis, management, and novel therapies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e6709299e1584832bc967422cf3e0cc3
work_keys_str_mv	AT chunfungsin earlytcellprecursoracutelymphoblasticleukemiadiagnosisupdatesinmolecularpathogenesismanagementandnoveltherapies AT puiheimarcusman earlytcellprecursoracutelymphoblasticleukemiadiagnosisupdatesinmolecularpathogenesismanagementandnoveltherapies
_version_	1718405207319117824

Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies

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