24-Hour Profiles of 11-Oxygenated C19 Steroids and Δ5-Steroid Sulfates during Oral and Continuous Subcutaneous Glucocorticoids in 21-Hydroxylase Deficiency

24-Hour Profiles of 11-Oxygenated C19 Steroids and Δ5-Steroid Sulfates during Oral and Continuous Subcutaneous Glucocorticoids in 21-Hydroxylase Deficiency

BackgroundOptimal management of androgen excess in 21-hydroxylase deficiency (21OHD) remains challenging. 11-oxygenated-C19 steroids (11-oxyandrogens) have emerged as promising biomarkers of disease control, but data regarding their response to treatment are lacking.ObjectiveTo compare the dynamic r...

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Bibliographic Details
Main Authors: Adina F. Turcu, Ashwini Mallappa, Aikaterini A. Nella, Xuan Chen, Lili Zhao, Aya T. Nanba, James Brian Byrd, Richard J. Auchus, Deborah P. Merke
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
21-hydroxylase deficiency
congenital adrenal hyperplasia
11-oxyandrogens
Circadian hormones
cortisol 24-hour profile
CAH
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Online Access:https://doaj.org/article/e678b04d9d664e889f9b3bec448def53
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https://doaj.org/article/e678b04d9d664e889f9b3bec448def53

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