Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP synergize to increase apoptosis in prostate cancer...
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Nature Portfolio
2020
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oai:doaj.org-article:e67ec780a1554759a4b84c3b9ee77ce52021-12-02T16:50:00ZPharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy10.1038/s41467-019-13950-42041-1723https://doaj.org/article/e67ec780a1554759a4b84c3b9ee77ce52020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13950-4https://doaj.org/toc/2041-1723Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP synergize to increase apoptosis in prostate cancer cells.Hayley C. AffrontiAryn M. RowsamAnthony J. PelleriteSpencer R. RosarioMark D. LongJustine J. JacobiAnna Bianchi-SmiragliaChristoph S. BoerlinBryan M. GillardEllen KarasikBarbara A. FosterMichael MoserJohn H. WiltonKristopher AttwoodMikhail A. NikiforovGissou AzabdaftariRoberto PiliJames G. PhillipsRobert A. CaseroDominic J. SmiragliaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hayley C. Affronti Aryn M. Rowsam Anthony J. Pellerite Spencer R. Rosario Mark D. Long Justine J. Jacobi Anna Bianchi-Smiraglia Christoph S. Boerlin Bryan M. Gillard Ellen Karasik Barbara A. Foster Michael Moser John H. Wilton Kristopher Attwood Mikhail A. Nikiforov Gissou Azabdaftari Roberto Pili James G. Phillips Robert A. Casero Dominic J. Smiraglia Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| description |
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP synergize to increase apoptosis in prostate cancer cells. |
| format |
article |
| author |
Hayley C. Affronti Aryn M. Rowsam Anthony J. Pellerite Spencer R. Rosario Mark D. Long Justine J. Jacobi Anna Bianchi-Smiraglia Christoph S. Boerlin Bryan M. Gillard Ellen Karasik Barbara A. Foster Michael Moser John H. Wilton Kristopher Attwood Mikhail A. Nikiforov Gissou Azabdaftari Roberto Pili James G. Phillips Robert A. Casero Dominic J. Smiraglia |
| author_facet |
Hayley C. Affronti Aryn M. Rowsam Anthony J. Pellerite Spencer R. Rosario Mark D. Long Justine J. Jacobi Anna Bianchi-Smiraglia Christoph S. Boerlin Bryan M. Gillard Ellen Karasik Barbara A. Foster Michael Moser John H. Wilton Kristopher Attwood Mikhail A. Nikiforov Gissou Azabdaftari Roberto Pili James G. Phillips Robert A. Casero Dominic J. Smiraglia |
| author_sort |
Hayley C. Affronti |
| title |
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| title_short |
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| title_full |
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| title_fullStr |
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| title_full_unstemmed |
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| title_sort |
pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/e67ec780a1554759a4b84c3b9ee77ce5 |
| work_keys_str_mv |
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1718383191364993024 |