Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women

Abstract A distinct bacterial signature of the placenta was reported, providing evidence that the fetus does not develop in a sterile environment. The oral microbiome was suggested as a possible source of the bacterial DNA present in the placenta based on similarities to the oral non-pregnant microb...

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Autores principales:	Luisa F. Gomez-Arango, Helen. L. Barrett, H. David McIntyre, Leonie K. Callaway, Mark Morrison, Marloes Dekker Nitert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e680a534b691418fad7bcbb564f6cab9
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spelling	oai:doaj.org-article:e680a534b691418fad7bcbb564f6cab92021-12-02T16:07:05ZContributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women10.1038/s41598-017-03066-42045-2322https://doaj.org/article/e680a534b691418fad7bcbb564f6cab92017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03066-4https://doaj.org/toc/2045-2322Abstract A distinct bacterial signature of the placenta was reported, providing evidence that the fetus does not develop in a sterile environment. The oral microbiome was suggested as a possible source of the bacterial DNA present in the placenta based on similarities to the oral non-pregnant microbiome. Here, the possible origin of the placental microbiome was assessed, examining the gut, oral and placental microbiomes from the same pregnant women. Microbiome profiles from 37 overweight and obese pregnant women were examined by 16SrRNA sequencing. Fecal and oral contributions to the establishment of the placental microbiome were evaluated. Core phylotypes between body sites and metagenome predictive functionality were determined. The placental microbiome showed a higher resemblance and phylogenetic proximity with the pregnant oral microbiome. However, similarity decreased at lower taxonomic levels and microbiomes clustered based on tissue origin. Core genera: Prevotella, Streptococcus and Veillonella were shared between all body compartments. Pathways encoding tryptophan, fatty-acid metabolism and benzoate degradation were highly enriched specifically in the placenta. Findings demonstrate that the placental microbiome exhibits a higher resemblance with the pregnant oral microbiome. Both oral and gut microbiomes contribute to the microbial seeding of the placenta, suggesting that placental colonization may have multiple niche sources.Luisa F. Gomez-ArangoHelen. L. BarrettH. David McIntyreLeonie K. CallawayMark MorrisonMarloes Dekker NitertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luisa F. Gomez-Arango Helen. L. Barrett H. David McIntyre Leonie K. Callaway Mark Morrison Marloes Dekker Nitert Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
description	Abstract A distinct bacterial signature of the placenta was reported, providing evidence that the fetus does not develop in a sterile environment. The oral microbiome was suggested as a possible source of the bacterial DNA present in the placenta based on similarities to the oral non-pregnant microbiome. Here, the possible origin of the placental microbiome was assessed, examining the gut, oral and placental microbiomes from the same pregnant women. Microbiome profiles from 37 overweight and obese pregnant women were examined by 16SrRNA sequencing. Fecal and oral contributions to the establishment of the placental microbiome were evaluated. Core phylotypes between body sites and metagenome predictive functionality were determined. The placental microbiome showed a higher resemblance and phylogenetic proximity with the pregnant oral microbiome. However, similarity decreased at lower taxonomic levels and microbiomes clustered based on tissue origin. Core genera: Prevotella, Streptococcus and Veillonella were shared between all body compartments. Pathways encoding tryptophan, fatty-acid metabolism and benzoate degradation were highly enriched specifically in the placenta. Findings demonstrate that the placental microbiome exhibits a higher resemblance with the pregnant oral microbiome. Both oral and gut microbiomes contribute to the microbial seeding of the placenta, suggesting that placental colonization may have multiple niche sources.
format	article
author	Luisa F. Gomez-Arango Helen. L. Barrett H. David McIntyre Leonie K. Callaway Mark Morrison Marloes Dekker Nitert
author_facet	Luisa F. Gomez-Arango Helen. L. Barrett H. David McIntyre Leonie K. Callaway Mark Morrison Marloes Dekker Nitert
author_sort	Luisa F. Gomez-Arango
title	Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
title_short	Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
title_full	Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
title_fullStr	Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
title_full_unstemmed	Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
title_sort	contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e680a534b691418fad7bcbb564f6cab9
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Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women

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