Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes

Abstract The association between rate of kidney function decline and age-of-onset or duration of diabetes has not been well investigated. We aimed to examine whether rates of estimated glomerular filtration rate (eGFR) decline differ by age-of-onset or duration in people with type 2 diabetes. Using...

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Autores principales:	Oyunchimeg Buyadaa, Agus Salim, Jedidiah I. Morton, Dianna J. Magliano, Jonathan E. Shaw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e68217fecab741b4a23c1fd7ef7e634d
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spelling	oai:doaj.org-article:e68217fecab741b4a23c1fd7ef7e634d2021-12-02T16:26:30ZRate of decline in kidney function and known age-of-onset or duration of type 2 diabetes10.1038/s41598-021-94099-32045-2322https://doaj.org/article/e68217fecab741b4a23c1fd7ef7e634d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94099-3https://doaj.org/toc/2045-2322Abstract The association between rate of kidney function decline and age-of-onset or duration of diabetes has not been well investigated. We aimed to examine whether rates of estimated glomerular filtration rate (eGFR) decline differ by age-of-onset or duration in people with type 2 diabetes. Using the Action to Control Cardiovascular Risk in Diabetes study which included those with HbA1c ≥ 7.5% and who were at high risk of cardiovascular events,, rates of eGFR decline were calculated and were compared among groups defined by the known age-of-onset (0–39, 40–49, 50–59, 60–69 and > 70 years) and 5-year diabetes duration intervals. Changes in renal function were evaluated using median of 6 (interquartile range 3–10) eGFR measurements per person. eGFR decline was the slowest in those with known age-at-diagnosis of 50–59 years or those with duration of diabetes < 5 years. The rates of eGFR decline were significantly greater in those with known age-of-onset < 40 years or those with duration of diabetes > 20 years compared to those diagnosed at 50–59 or those with duration of diabetes < 5 years (− 1.98 vs − 1.61 mL/min/year; − 1.82 vs − 1.52 mL/min/year; respectively (p < 0.001). Those with youngest age-of-onset or longer duration of diabetes had more rapid declines in eGFR compared to those diagnosed at middle age or those with shorter duration of diabetes.Oyunchimeg BuyadaaAgus SalimJedidiah I. MortonDianna J. MaglianoJonathan E. ShawNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oyunchimeg Buyadaa Agus Salim Jedidiah I. Morton Dianna J. Magliano Jonathan E. Shaw Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
description	Abstract The association between rate of kidney function decline and age-of-onset or duration of diabetes has not been well investigated. We aimed to examine whether rates of estimated glomerular filtration rate (eGFR) decline differ by age-of-onset or duration in people with type 2 diabetes. Using the Action to Control Cardiovascular Risk in Diabetes study which included those with HbA1c ≥ 7.5% and who were at high risk of cardiovascular events,, rates of eGFR decline were calculated and were compared among groups defined by the known age-of-onset (0–39, 40–49, 50–59, 60–69 and > 70 years) and 5-year diabetes duration intervals. Changes in renal function were evaluated using median of 6 (interquartile range 3–10) eGFR measurements per person. eGFR decline was the slowest in those with known age-at-diagnosis of 50–59 years or those with duration of diabetes < 5 years. The rates of eGFR decline were significantly greater in those with known age-of-onset < 40 years or those with duration of diabetes > 20 years compared to those diagnosed at 50–59 or those with duration of diabetes < 5 years (− 1.98 vs − 1.61 mL/min/year; − 1.82 vs − 1.52 mL/min/year; respectively (p < 0.001). Those with youngest age-of-onset or longer duration of diabetes had more rapid declines in eGFR compared to those diagnosed at middle age or those with shorter duration of diabetes.
format	article
author	Oyunchimeg Buyadaa Agus Salim Jedidiah I. Morton Dianna J. Magliano Jonathan E. Shaw
author_facet	Oyunchimeg Buyadaa Agus Salim Jedidiah I. Morton Dianna J. Magliano Jonathan E. Shaw
author_sort	Oyunchimeg Buyadaa
title	Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
title_short	Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
title_full	Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
title_fullStr	Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
title_full_unstemmed	Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
title_sort	rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e68217fecab741b4a23c1fd7ef7e634d
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Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes

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