Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia

Amyotrophic Lateral Sclerosis is a neurological disease that primarily affects motor neurons in the cortex, brainstem, and spinal cord. The process that leads to motor neuron degeneration is strongly influenced by non-motor neuronal events that occur in a variety of cell types. Among these, neuroinf...

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Autores principales:	Simona Rossi, Mauro Cozzolino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Amyotrophic Lateral Sclerosis neuroinflammation RNA metabolism RNA-binding proteins astrocytes microglia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e68343dc115841faa8d8f5947d13a85e
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spelling	oai:doaj.org-article:e68343dc115841faa8d8f5947d13a85e2021-11-25T17:10:19ZDysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia10.3390/cells101130052073-4409https://doaj.org/article/e68343dc115841faa8d8f5947d13a85e2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3005https://doaj.org/toc/2073-4409Amyotrophic Lateral Sclerosis is a neurological disease that primarily affects motor neurons in the cortex, brainstem, and spinal cord. The process that leads to motor neuron degeneration is strongly influenced by non-motor neuronal events that occur in a variety of cell types. Among these, neuroinflammatory processes mediated by activated astrocytes and microglia play a relevant role. In recent years, it has become clear that dysregulation of essential steps of RNA metabolism, as a consequence of alterations in RNA-binding proteins (RBPs), is a central event in the degeneration of motor neurons. Yet, a causal link between dysfunctional RNA metabolism and the neuroinflammatory processes mediated by astrocytes and microglia in ALS has been poorly defined. In this review, we will discuss the available evidence showing that RBPs and associated RNA processing are affected in ALS astrocytes and microglia, and the possible mechanisms involved in these events.Simona RossiMauro CozzolinoMDPI AGarticleAmyotrophic Lateral SclerosisneuroinflammationRNA metabolismRNA-binding proteinsastrocytesmicrogliaBiology (General)QH301-705.5ENCells, Vol 10, Iss 3005, p 3005 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amyotrophic Lateral Sclerosis neuroinflammation RNA metabolism RNA-binding proteins astrocytes microglia Biology (General) QH301-705.5
spellingShingle	Amyotrophic Lateral Sclerosis neuroinflammation RNA metabolism RNA-binding proteins astrocytes microglia Biology (General) QH301-705.5 Simona Rossi Mauro Cozzolino Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
description	Amyotrophic Lateral Sclerosis is a neurological disease that primarily affects motor neurons in the cortex, brainstem, and spinal cord. The process that leads to motor neuron degeneration is strongly influenced by non-motor neuronal events that occur in a variety of cell types. Among these, neuroinflammatory processes mediated by activated astrocytes and microglia play a relevant role. In recent years, it has become clear that dysregulation of essential steps of RNA metabolism, as a consequence of alterations in RNA-binding proteins (RBPs), is a central event in the degeneration of motor neurons. Yet, a causal link between dysfunctional RNA metabolism and the neuroinflammatory processes mediated by astrocytes and microglia in ALS has been poorly defined. In this review, we will discuss the available evidence showing that RBPs and associated RNA processing are affected in ALS astrocytes and microglia, and the possible mechanisms involved in these events.
format	article
author	Simona Rossi Mauro Cozzolino
author_facet	Simona Rossi Mauro Cozzolino
author_sort	Simona Rossi
title	Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
title_short	Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
title_full	Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
title_fullStr	Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
title_full_unstemmed	Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
title_sort	dysfunction of rna/rna-binding proteins in als astrocytes and microglia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e68343dc115841faa8d8f5947d13a85e
work_keys_str_mv	AT simonarossi dysfunctionofrnarnabindingproteinsinalsastrocytesandmicroglia AT maurocozzolino dysfunctionofrnarnabindingproteinsinalsastrocytesandmicroglia
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Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia

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