Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

5-hydroxythalidomide is a primary thalidomide metabolite generated by the cytochrome P450 isozymes. The reported data, including crystal structure of the 5-hydroxythalidomide-mediated complex of CRBN with SALL4, elucidate how additional hydroxy group of the metabolite enhances the interaction of CRB...

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Autores principales:	Hirotake Furihata, Satoshi Yamanaka, Toshiaki Honda, Yumiko Miyauchi, Atsuko Asano, Norio Shibata, Masaru Tanokura, Tatsuya Sawasaki, Takuya Miyakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6839866ce1b4a9fbf178c9bea0007d2
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spelling	oai:doaj.org-article:e6839866ce1b4a9fbf178c9bea0007d22021-12-02T18:34:03ZStructural bases of IMiD selectivity that emerges by 5-hydroxythalidomide10.1038/s41467-020-18488-42041-1723https://doaj.org/article/e6839866ce1b4a9fbf178c9bea0007d22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18488-4https://doaj.org/toc/2041-17235-hydroxythalidomide is a primary thalidomide metabolite generated by the cytochrome P450 isozymes. The reported data, including crystal structure of the 5-hydroxythalidomide-mediated complex of CRBN with SALL4, elucidate how additional hydroxy group of the metabolite enhances the interaction of CRBN with the neosubstrate SALL4.Hirotake FurihataSatoshi YamanakaToshiaki HondaYumiko MiyauchiAtsuko AsanoNorio ShibataMasaru TanokuraTatsuya SawasakiTakuya MiyakawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hirotake Furihata Satoshi Yamanaka Toshiaki Honda Yumiko Miyauchi Atsuko Asano Norio Shibata Masaru Tanokura Tatsuya Sawasaki Takuya Miyakawa Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
description	5-hydroxythalidomide is a primary thalidomide metabolite generated by the cytochrome P450 isozymes. The reported data, including crystal structure of the 5-hydroxythalidomide-mediated complex of CRBN with SALL4, elucidate how additional hydroxy group of the metabolite enhances the interaction of CRBN with the neosubstrate SALL4.
format	article
author	Hirotake Furihata Satoshi Yamanaka Toshiaki Honda Yumiko Miyauchi Atsuko Asano Norio Shibata Masaru Tanokura Tatsuya Sawasaki Takuya Miyakawa
author_facet	Hirotake Furihata Satoshi Yamanaka Toshiaki Honda Yumiko Miyauchi Atsuko Asano Norio Shibata Masaru Tanokura Tatsuya Sawasaki Takuya Miyakawa
author_sort	Hirotake Furihata
title	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
title_short	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
title_full	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
title_fullStr	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
title_full_unstemmed	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
title_sort	structural bases of imid selectivity that emerges by 5-hydroxythalidomide
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e6839866ce1b4a9fbf178c9bea0007d2
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Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

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