Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis

Aim. To study the prevalence of androgen deficiency in men with type 1 diabetes mellitus (DM1) undergoing programmed hemodialysis (PHD) andto develop methods for the treatment of metabolic disorders. Materials and methods. The study included 43 men with DM1 on PHD. Group 1 comprised 20 patients be...

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Autores principales:	Alexander Evgen'evich Lepetukhin, Nikolay Petrovich Goncharov, Anatoliy Ivanovich Mordik, Natalya Yur'evna Biskaeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	diabetes mellitus androgen deficiency hemodialysis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/e684033e3f4a4eff8bbff59a4ce1093d
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spelling	oai:doaj.org-article:e684033e3f4a4eff8bbff59a4ce1093d2021-11-14T09:00:14ZHormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis2072-03512072-037810.14341/2072-0351-6013https://doaj.org/article/e684033e3f4a4eff8bbff59a4ce1093d2010-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6013https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study the prevalence of androgen deficiency in men with type 1 diabetes mellitus (DM1) undergoing programmed hemodialysis (PHD) andto develop methods for the treatment of metabolic disorders. Materials and methods. The study included 43 men with DM1 on PHD. Group 1 comprised 20 patients below 40 years of age, group 2 included23 older patients. Patients of group 1 were allocated to subgroup A (treated with testosterone and ether mixture (TEM)); and control subgroup B(n=14 and 6 respectively). Patients of group 2 were divided into subgroup C (treated with TEM) and control subgroup D (n=14 and 9 respectively).Patients in the study and control subgroups were matched for age, duration of DM1, hemodialysis (years), total testosterone (TT, nmol/l), hemoglobin(Hb, g/l) and glycated hemoglobin (HbA1c, %) levels. All the patients were treated with epoetin-beta (EPO-b) on an individual basis depending onHb level; TEM was given thrice weekly. Results. Group 1: age 34.0?3.9 yr, HbA1c 9.3?1.4%, Hb 118.1?9.6 g/l, TT 21.2?6.6 nmol/l. Group 1: age 47.3?3.5 yr, HbA1c 9.5?1.8%,Hb 94.9?5.7 g/l, TT 9.8?3.9 nmol/l. Androgen deficiency was diagnosed in 48.8% (total group), 5.0% (group 1) and 86.9% (group 2) of the patients.Reduction of TT level was not accompanied by a significant rise in LH concentration to above normal values (p>0.05). HbA1c level in eithergroup did not significantly change within 6 months after the onset of the study. Combined treatment with EPO-b and TEM resulted in a Hb concentrationof 118.2?6.7 g/l in subgroup A (p=0.79). Hb level in subgroup C increased to 113.5?6.3 g/l (p=0.009). Hb changes in control groups wereinsignificant. Requirement for EPO-b in subgroups A and C decreased by 32.1% (p=0.007) and 41.1% (p=0.001) respectively but remained unalteredin both control subgroups. Conclusion. Reduction of the TT level in men with DM1 on PHD is a function of age and constitutes an independent risk factor of anemia. Androgendeficiency and its correction have no effect on carbohydrate metabolism. Combined treatment with EPO-b and TEM increases blood Hb level in oldermen and reduces requirement for EPO-b regardless of the age.Alexander Evgen'evich LepetukhinNikolay Petrovich GoncharovAnatoliy Ivanovich MordikNatalya Yur'evna BiskaevaEndocrinology Research Centrearticlediabetes mellitusandrogen deficiencyhemodialysisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 1, Pp 27-32 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus androgen deficiency hemodialysis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus androgen deficiency hemodialysis Nutritional diseases. Deficiency diseases RC620-627 Alexander Evgen'evich Lepetukhin Nikolay Petrovich Goncharov Anatoliy Ivanovich Mordik Natalya Yur'evna Biskaeva Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
description	Aim. To study the prevalence of androgen deficiency in men with type 1 diabetes mellitus (DM1) undergoing programmed hemodialysis (PHD) andto develop methods for the treatment of metabolic disorders. Materials and methods. The study included 43 men with DM1 on PHD. Group 1 comprised 20 patients below 40 years of age, group 2 included23 older patients. Patients of group 1 were allocated to subgroup A (treated with testosterone and ether mixture (TEM)); and control subgroup B(n=14 and 6 respectively). Patients of group 2 were divided into subgroup C (treated with TEM) and control subgroup D (n=14 and 9 respectively).Patients in the study and control subgroups were matched for age, duration of DM1, hemodialysis (years), total testosterone (TT, nmol/l), hemoglobin(Hb, g/l) and glycated hemoglobin (HbA1c, %) levels. All the patients were treated with epoetin-beta (EPO-b) on an individual basis depending onHb level; TEM was given thrice weekly. Results. Group 1: age 34.0?3.9 yr, HbA1c 9.3?1.4%, Hb 118.1?9.6 g/l, TT 21.2?6.6 nmol/l. Group 1: age 47.3?3.5 yr, HbA1c 9.5?1.8%,Hb 94.9?5.7 g/l, TT 9.8?3.9 nmol/l. Androgen deficiency was diagnosed in 48.8% (total group), 5.0% (group 1) and 86.9% (group 2) of the patients.Reduction of TT level was not accompanied by a significant rise in LH concentration to above normal values (p>0.05). HbA1c level in eithergroup did not significantly change within 6 months after the onset of the study. Combined treatment with EPO-b and TEM resulted in a Hb concentrationof 118.2?6.7 g/l in subgroup A (p=0.79). Hb level in subgroup C increased to 113.5?6.3 g/l (p=0.009). Hb changes in control groups wereinsignificant. Requirement for EPO-b in subgroups A and C decreased by 32.1% (p=0.007) and 41.1% (p=0.001) respectively but remained unalteredin both control subgroups. Conclusion. Reduction of the TT level in men with DM1 on PHD is a function of age and constitutes an independent risk factor of anemia. Androgendeficiency and its correction have no effect on carbohydrate metabolism. Combined treatment with EPO-b and TEM increases blood Hb level in oldermen and reduces requirement for EPO-b regardless of the age.
format	article
author	Alexander Evgen'evich Lepetukhin Nikolay Petrovich Goncharov Anatoliy Ivanovich Mordik Natalya Yur'evna Biskaeva
author_facet	Alexander Evgen'evich Lepetukhin Nikolay Petrovich Goncharov Anatoliy Ivanovich Mordik Natalya Yur'evna Biskaeva
author_sort	Alexander Evgen'evich Lepetukhin
title	Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
title_short	Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
title_full	Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
title_fullStr	Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
title_full_unstemmed	Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
title_sort	hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/e684033e3f4a4eff8bbff59a4ce1093d
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Hormonal and metabolic characteristic of androgen deficiency and its correction by testosterone in men with type 1 diabetes mellitusundergoing programmed hemodialysis

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