ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER

Objective: To evaluate immunohistochemical expression of EGFR in colorectal cancer (CRC). Study Design: Descriptive cross sectional study. Place and Duration of Study: Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Mar 2017 to Aug 2017. Methodology:...

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Autores principales:	Ghazala Sadaf, Muhammad Tahir Khadim, Rabia Ahmed, Muhammad Asif
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	anti-egfr therapy colorectal cancer epidermal growth factor receptor immunohistochemistry Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e684ea4c9ca249859dee3b653965a868
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spelling	oai:doaj.org-article:e684ea4c9ca249859dee3b653965a8682021-12-02T17:38:58ZANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER0030-96482411-8842https://doaj.org/article/e684ea4c9ca249859dee3b653965a8682020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5549https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate immunohistochemical expression of EGFR in colorectal cancer (CRC). Study Design: Descriptive cross sectional study. Place and Duration of Study: Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Mar 2017 to Aug 2017. Methodology: A total of 100 cases of histologically confirmed CRC were retrieved from archive of Histopathology department, AFIP Rawalpindi. Patients’ age, gender, histologic type and grade were noted. Immunohistochemistry for EGFR was applied and results were recorded. Data was analyzed using SPSS version 22. Descriptive statistics, frequencies and percentages were calculated. Results: A total of hundred (n=100) patients were enrolled. Mean age of the study patients was 54.3 ± 16.3 years. The group of patients consisted of 68 (68%) men and 32 (32%) women. The majority of primary tumours were located in the rectum 39, (39%), followed by ascending colon 16 (16%), rectosigmoid junction 14 (14%), cecum 13 (13%), sigmoid colon 9 (9%), transverse colon 5 (5%) and descending colon 4 (4%). Most frequent histologic type was adenocarcinoma 80 (80%), followed by mucinous adenocarcinoma 12, (12%) and signet ring cell carcinoma 8 (8%). Most tumours were moderately differentiated 47 (47%), followed by well differentiated 34 (34%) and poorly differentiated 19 (19%). EGFR expression was found in 39 cases (39%). Among adenocarcinoma 41% (n=33/80) were EGFR positive and among mucinous adenocarcinoma 50% (n=6/12) were EGFR positive. All signet ring cell carcinoma cases were EGFR negative. Among well differentiated CRCs 41% (n=14/34) were EGFR positive, among moderately differentiated 40% (n=19/47) were EGFR positive and among poorly differentiated 46% (n=6/13) were EGFR positive. Conclusion: A significant percentage of CRC expressed EGFR but no statistically significant correlation was seen between EGFR expression and clinicopathological variables. Estimation of EGFR expression status may help to select the patients with CRC for targeted therapy, which is likely to improve the response rates.Ghazala SadafMuhammad Tahir KhadimRabia AhmedMuhammad AsifArmy Medical College Rawalpindiarticleanti-egfr therapycolorectal cancerepidermal growth factor receptorimmunohistochemistryMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1277-1282 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-egfr therapy colorectal cancer epidermal growth factor receptor immunohistochemistry Medicine R Medicine (General) R5-920
spellingShingle	anti-egfr therapy colorectal cancer epidermal growth factor receptor immunohistochemistry Medicine R Medicine (General) R5-920 Ghazala Sadaf Muhammad Tahir Khadim Rabia Ahmed Muhammad Asif ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER
description	Objective: To evaluate immunohistochemical expression of EGFR in colorectal cancer (CRC). Study Design: Descriptive cross sectional study. Place and Duration of Study: Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Mar 2017 to Aug 2017. Methodology: A total of 100 cases of histologically confirmed CRC were retrieved from archive of Histopathology department, AFIP Rawalpindi. Patients’ age, gender, histologic type and grade were noted. Immunohistochemistry for EGFR was applied and results were recorded. Data was analyzed using SPSS version 22. Descriptive statistics, frequencies and percentages were calculated. Results: A total of hundred (n=100) patients were enrolled. Mean age of the study patients was 54.3 ± 16.3 years. The group of patients consisted of 68 (68%) men and 32 (32%) women. The majority of primary tumours were located in the rectum 39, (39%), followed by ascending colon 16 (16%), rectosigmoid junction 14 (14%), cecum 13 (13%), sigmoid colon 9 (9%), transverse colon 5 (5%) and descending colon 4 (4%). Most frequent histologic type was adenocarcinoma 80 (80%), followed by mucinous adenocarcinoma 12, (12%) and signet ring cell carcinoma 8 (8%). Most tumours were moderately differentiated 47 (47%), followed by well differentiated 34 (34%) and poorly differentiated 19 (19%). EGFR expression was found in 39 cases (39%). Among adenocarcinoma 41% (n=33/80) were EGFR positive and among mucinous adenocarcinoma 50% (n=6/12) were EGFR positive. All signet ring cell carcinoma cases were EGFR negative. Among well differentiated CRCs 41% (n=14/34) were EGFR positive, among moderately differentiated 40% (n=19/47) were EGFR positive and among poorly differentiated 46% (n=6/13) were EGFR positive. Conclusion: A significant percentage of CRC expressed EGFR but no statistically significant correlation was seen between EGFR expression and clinicopathological variables. Estimation of EGFR expression status may help to select the patients with CRC for targeted therapy, which is likely to improve the response rates.
format	article
author	Ghazala Sadaf Muhammad Tahir Khadim Rabia Ahmed Muhammad Asif
author_facet	Ghazala Sadaf Muhammad Tahir Khadim Rabia Ahmed Muhammad Asif
author_sort	Ghazala Sadaf
title	ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER
title_short	ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER
title_full	ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER
title_fullStr	ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER
title_full_unstemmed	ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER
title_sort	analysis of immunohistochemical expression of epidermal growth factor receptor (egfr) in colorectal cancer
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/e684ea4c9ca249859dee3b653965a868
work_keys_str_mv	AT ghazalasadaf analysisofimmunohistochemicalexpressionofepidermalgrowthfactorreceptoregfrincolorectalcancer AT muhammadtahirkhadim analysisofimmunohistochemicalexpressionofepidermalgrowthfactorreceptoregfrincolorectalcancer AT rabiaahmed analysisofimmunohistochemicalexpressionofepidermalgrowthfactorreceptoregfrincolorectalcancer AT muhammadasif analysisofimmunohistochemicalexpressionofepidermalgrowthfactorreceptoregfrincolorectalcancer
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ANALYSIS OF IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER

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