Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study

Abstract Adjuvant radiotherapy (RT) for breast cancer (BC) has been associated with an increased risk of later radiation-induced lung cancer (LC). We examined the risk of primary LC in a population-based cohort of 52300 women treated for BC during 1992 to 2012, and 253796 age-matched women without B...

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Autores principales:	Anna-Karin Wennstig, Charlotta Wadsten, Hans Garmo, Mikael Johansson, Irma Fredriksson, Carl Blomqvist, Lars Holmberg, Greger Nilsson, Malin Sund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e68af3e3cd214a77a9980ef29abb98aa
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spelling	oai:doaj.org-article:e68af3e3cd214a77a9980ef29abb98aa2021-12-02T15:02:54ZRisk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study10.1038/s41523-021-00280-22374-4677https://doaj.org/article/e68af3e3cd214a77a9980ef29abb98aa2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00280-2https://doaj.org/toc/2374-4677Abstract Adjuvant radiotherapy (RT) for breast cancer (BC) has been associated with an increased risk of later radiation-induced lung cancer (LC). We examined the risk of primary LC in a population-based cohort of 52300 women treated for BC during 1992 to 2012, and 253796 age-matched women without BC. Cumulative incidence of LC was calculated by the Kaplan–Meier method, and the risk of LC after BC treatment was estimated by Cox proportional hazards regression analyses. Women with BC receiving RT had a higher cumulative incidence of LC compared to women with BC not receiving RT and women without BC. This became apparent 5 years after RT and increased with longer follow-up. Women with BC receiving RT had a Hazard ratio of 1.59 (95% confidence interval 1.37–1.84) for LC compared to women without BC. RT techniques that lower the incidental lung doses, e.g breathing adaption techniques, may lower this risk.Anna-Karin WennstigCharlotta WadstenHans GarmoMikael JohanssonIrma FredrikssonCarl BlomqvistLars HolmbergGreger NilssonMalin SundNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Anna-Karin Wennstig Charlotta Wadsten Hans Garmo Mikael Johansson Irma Fredriksson Carl Blomqvist Lars Holmberg Greger Nilsson Malin Sund Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
description	Abstract Adjuvant radiotherapy (RT) for breast cancer (BC) has been associated with an increased risk of later radiation-induced lung cancer (LC). We examined the risk of primary LC in a population-based cohort of 52300 women treated for BC during 1992 to 2012, and 253796 age-matched women without BC. Cumulative incidence of LC was calculated by the Kaplan–Meier method, and the risk of LC after BC treatment was estimated by Cox proportional hazards regression analyses. Women with BC receiving RT had a higher cumulative incidence of LC compared to women with BC not receiving RT and women without BC. This became apparent 5 years after RT and increased with longer follow-up. Women with BC receiving RT had a Hazard ratio of 1.59 (95% confidence interval 1.37–1.84) for LC compared to women without BC. RT techniques that lower the incidental lung doses, e.g breathing adaption techniques, may lower this risk.
format	article
author	Anna-Karin Wennstig Charlotta Wadsten Hans Garmo Mikael Johansson Irma Fredriksson Carl Blomqvist Lars Holmberg Greger Nilsson Malin Sund
author_facet	Anna-Karin Wennstig Charlotta Wadsten Hans Garmo Mikael Johansson Irma Fredriksson Carl Blomqvist Lars Holmberg Greger Nilsson Malin Sund
author_sort	Anna-Karin Wennstig
title	Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
title_short	Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
title_full	Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
title_fullStr	Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
title_full_unstemmed	Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
title_sort	risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e68af3e3cd214a77a9980ef29abb98aa
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Risk of primary lung cancer after adjuvant radiotherapy in breast cancer—a large population-based study

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