Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming
Objectives: Deep brain stimulation (DBS) programming is based on clinical response testing. Our clinical pilot trial assessed the feasibility of image-guided programing using software depicting the lead location in a patient-specific anatomical model.Methods: Parkinson's disease patients with s...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e68baf6ac36d4c79bc8feb874ce91565 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e68baf6ac36d4c79bc8feb874ce91565 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e68baf6ac36d4c79bc8feb874ce915652021-11-08T07:48:24ZReduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming1664-229510.3389/fneur.2021.785529https://doaj.org/article/e68baf6ac36d4c79bc8feb874ce915652021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.785529/fullhttps://doaj.org/toc/1664-2295Objectives: Deep brain stimulation (DBS) programming is based on clinical response testing. Our clinical pilot trial assessed the feasibility of image-guided programing using software depicting the lead location in a patient-specific anatomical model.Methods: Parkinson's disease patients with subthalamic nucleus-DBS were randomly assigned to standard clinical-based programming (CBP) or anatomical-based (imaging-guided) programming (ABP) in an 8-week crossover trial. Programming characteristics and clinical outcomes were evaluated.Results: In 10 patients, both programs led to similar motor symptom control (MDS-UPDRS III) after 4 weeks (medicationOFF/stimulationON; CPB: 18.27 ± 9.23; ABP: 18.37 ± 6.66). Stimulation settings were not significantly different, apart from higher frequency in the baseline program than CBP (p = 0.01) or ABP (p = 0.003). Time spent in a program was not significantly different (CBP: 86.1 ± 29.82%, ABP: 88.6 ± 29.0%). Programing time was significantly shorter (p = 0.039) with ABP (19.78 ± 5.86 min) than CBP (45.22 ± 18.32).Conclusion: Image-guided DBS programming in PD patients drastically reduces programming time without compromising symptom control and patient satisfaction in this small feasibility trial.Florian LangeFrank SteigerwaldTobias MalzacherGregor Alexander BrandtThorsten Michael OdorferJonas RoothansMartin M. ReichPatrick FrickeJens VolkmannCordula MatthiesPhilipp D. CapetianFrontiers Media S.A.articledirectional deep brain stimulationimage-guided programmingsubthalamic nucleuschronic stimulationrandomized controlled double-blind studyParkinson's diseaseNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
directional deep brain stimulation image-guided programming subthalamic nucleus chronic stimulation randomized controlled double-blind study Parkinson's disease Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
directional deep brain stimulation image-guided programming subthalamic nucleus chronic stimulation randomized controlled double-blind study Parkinson's disease Neurology. Diseases of the nervous system RC346-429 Florian Lange Frank Steigerwald Tobias Malzacher Gregor Alexander Brandt Thorsten Michael Odorfer Jonas Roothans Martin M. Reich Patrick Fricke Jens Volkmann Cordula Matthies Philipp D. Capetian Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming |
| description |
Objectives: Deep brain stimulation (DBS) programming is based on clinical response testing. Our clinical pilot trial assessed the feasibility of image-guided programing using software depicting the lead location in a patient-specific anatomical model.Methods: Parkinson's disease patients with subthalamic nucleus-DBS were randomly assigned to standard clinical-based programming (CBP) or anatomical-based (imaging-guided) programming (ABP) in an 8-week crossover trial. Programming characteristics and clinical outcomes were evaluated.Results: In 10 patients, both programs led to similar motor symptom control (MDS-UPDRS III) after 4 weeks (medicationOFF/stimulationON; CPB: 18.27 ± 9.23; ABP: 18.37 ± 6.66). Stimulation settings were not significantly different, apart from higher frequency in the baseline program than CBP (p = 0.01) or ABP (p = 0.003). Time spent in a program was not significantly different (CBP: 86.1 ± 29.82%, ABP: 88.6 ± 29.0%). Programing time was significantly shorter (p = 0.039) with ABP (19.78 ± 5.86 min) than CBP (45.22 ± 18.32).Conclusion: Image-guided DBS programming in PD patients drastically reduces programming time without compromising symptom control and patient satisfaction in this small feasibility trial. |
| format |
article |
| author |
Florian Lange Frank Steigerwald Tobias Malzacher Gregor Alexander Brandt Thorsten Michael Odorfer Jonas Roothans Martin M. Reich Patrick Fricke Jens Volkmann Cordula Matthies Philipp D. Capetian |
| author_facet |
Florian Lange Frank Steigerwald Tobias Malzacher Gregor Alexander Brandt Thorsten Michael Odorfer Jonas Roothans Martin M. Reich Patrick Fricke Jens Volkmann Cordula Matthies Philipp D. Capetian |
| author_sort |
Florian Lange |
| title |
Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming |
| title_short |
Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming |
| title_full |
Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming |
| title_fullStr |
Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming |
| title_full_unstemmed |
Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming |
| title_sort |
reduced programming time and strong symptom control even in chronic course through imaging-based dbs programming |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/e68baf6ac36d4c79bc8feb874ce91565 |
| work_keys_str_mv |
AT florianlange reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT franksteigerwald reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT tobiasmalzacher reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT gregoralexanderbrandt reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT thorstenmichaelodorfer reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT jonasroothans reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT martinmreich reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT patrickfricke reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT jensvolkmann reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT cordulamatthies reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming AT philippdcapetian reducedprogrammingtimeandstrongsymptomcontroleveninchroniccoursethroughimagingbaseddbsprogramming |
| _version_ |
1718442861711589376 |