Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

Abstract In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood cells preferentially recruit Disc large homolog 1 (Dl...

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Autores principales: Alexandra Zanin-Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan, Bruce R. Blazar, Michael L. Dustin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/e68bbe646c9d458cb1c2346218358f5d
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