Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress

Abstract Once disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition of DTCs in a latent state remains unclear. Here, we applied high-resolution DNA barcode tracking to a mouse model that recapitulated...

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Main Authors: Manabu Maeshiro, Satoru Shinriki, Rin Liu, Yutaka Nakachi, Yoshihiro Komohara, Yukio Fujiwara, Kazuaki Ohtsubo, Ryoji Yoshida, Kazuya Iwamoto, Hideki Nakayama, Hirotaka Matsui
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/e68d442039ad4d76bd6f2a98e8a7ffa0
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