Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction

Magnetic resonance imaging (MRI) can potentially be used for non-invasive screening of patients with stable angina pectoris to identify probable obstructive coronary artery disease. MRI-based coronary blood flow quantification has to date only been performed in a 2D fashion, limiting its clinical ap...

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Autores principales:	Carmen P. S. Blanken, Eric M. Schrauben, Eva S. Peper, Lukas M. Gottwald, Bram F. Coolen, Diederik F. van Wijk, Jan J. Piek, Gustav J. Strijkers, R. Nils Planken, Pim van Ooij, Aart J. Nederveen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	left coronary artery blood flow quantification 4D flow MRI 2D flow MRI respiratory motion correction Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/e68d5c9679174e3fb1323c50b97e0049
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spelling	oai:doaj.org-article:e68d5c9679174e3fb1323c50b97e00492021-11-08T10:48:33ZCoronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction2296-418510.3389/fbioe.2021.725833https://doaj.org/article/e68d5c9679174e3fb1323c50b97e00492021-08-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.725833/fullhttps://doaj.org/toc/2296-4185Magnetic resonance imaging (MRI) can potentially be used for non-invasive screening of patients with stable angina pectoris to identify probable obstructive coronary artery disease. MRI-based coronary blood flow quantification has to date only been performed in a 2D fashion, limiting its clinical applicability. In this study, we propose a framework for coronary blood flow quantification using accelerated 4D flow MRI with respiratory motion correction and compressed sensing image reconstruction. We investigate its feasibility and repeatability in healthy subjects at rest. Fourteen healthy subjects received 8 times-accelerated 4D flow MRI covering the left coronary artery (LCA) with an isotropic spatial resolution of 1.0 mm3. Respiratory motion correction was performed based on 1) lung-liver navigator signal, 2) real-time monitoring of foot-head motion of the liver and LCA by a separate acquisition, and 3) rigid image registration to correct for anterior-posterior motion. Time-averaged diastolic LCA flow was determined, as well as time-averaged diastolic maximal velocity (VMAX) and diastolic peak velocity (VPEAK). 2D flow MRI scans of the LCA were acquired for reference. Scan-rescan repeatability and agreement between 4D flow MRI and 2D flow MRI were assessed in terms of concordance correlation coefficient (CCC) and coefficient of variation (CV). The protocol resulted in good visibility of the LCA in 11 out of 14 subjects (six female, five male, aged 28 ± 4 years). The other 3 subjects were excluded from analysis. Time-averaged diastolic LCA flow measured by 4D flow MRI was 1.30 ± 0.39 ml/s and demonstrated good scan-rescan repeatability (CCC/CV = 0.79/20.4%). Time-averaged diastolic VMAX (17.2 ± 3.0 cm/s) and diastolic VPEAK (24.4 ± 6.5 cm/s) demonstrated moderate repeatability (CCC/CV = 0.52/19.0% and 0.68/23.0%, respectively). 4D flow- and 2D flow-based diastolic LCA flow agreed well (CCC/CV = 0.75/20.1%). Agreement between 4D flow MRI and 2D flow MRI was moderate for both diastolic VMAX and VPEAK (CCC/CV = 0.68/20.3% and 0.53/27.0%, respectively). In conclusion, the proposed framework of accelerated 4D flow MRI equipped with respiratory motion correction and compressed sensing image reconstruction enables repeatable diastolic LCA flow quantification that agrees well with 2D flow MRI.Carmen P. S. BlankenEric M. SchraubenEva S. PeperLukas M. GottwaldBram F. CoolenDiederik F. van WijkJan J. PiekGustav J. StrijkersR. Nils PlankenPim van OoijAart J. NederveenFrontiers Media S.A.articleleft coronary arteryblood flow quantification4D flow MRI2D flow MRIrespiratory motion correctionBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	left coronary artery blood flow quantification 4D flow MRI 2D flow MRI respiratory motion correction Biotechnology TP248.13-248.65
spellingShingle	left coronary artery blood flow quantification 4D flow MRI 2D flow MRI respiratory motion correction Biotechnology TP248.13-248.65 Carmen P. S. Blanken Eric M. Schrauben Eva S. Peper Lukas M. Gottwald Bram F. Coolen Diederik F. van Wijk Jan J. Piek Gustav J. Strijkers R. Nils Planken Pim van Ooij Aart J. Nederveen Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
description	Magnetic resonance imaging (MRI) can potentially be used for non-invasive screening of patients with stable angina pectoris to identify probable obstructive coronary artery disease. MRI-based coronary blood flow quantification has to date only been performed in a 2D fashion, limiting its clinical applicability. In this study, we propose a framework for coronary blood flow quantification using accelerated 4D flow MRI with respiratory motion correction and compressed sensing image reconstruction. We investigate its feasibility and repeatability in healthy subjects at rest. Fourteen healthy subjects received 8 times-accelerated 4D flow MRI covering the left coronary artery (LCA) with an isotropic spatial resolution of 1.0 mm3. Respiratory motion correction was performed based on 1) lung-liver navigator signal, 2) real-time monitoring of foot-head motion of the liver and LCA by a separate acquisition, and 3) rigid image registration to correct for anterior-posterior motion. Time-averaged diastolic LCA flow was determined, as well as time-averaged diastolic maximal velocity (VMAX) and diastolic peak velocity (VPEAK). 2D flow MRI scans of the LCA were acquired for reference. Scan-rescan repeatability and agreement between 4D flow MRI and 2D flow MRI were assessed in terms of concordance correlation coefficient (CCC) and coefficient of variation (CV). The protocol resulted in good visibility of the LCA in 11 out of 14 subjects (six female, five male, aged 28 ± 4 years). The other 3 subjects were excluded from analysis. Time-averaged diastolic LCA flow measured by 4D flow MRI was 1.30 ± 0.39 ml/s and demonstrated good scan-rescan repeatability (CCC/CV = 0.79/20.4%). Time-averaged diastolic VMAX (17.2 ± 3.0 cm/s) and diastolic VPEAK (24.4 ± 6.5 cm/s) demonstrated moderate repeatability (CCC/CV = 0.52/19.0% and 0.68/23.0%, respectively). 4D flow- and 2D flow-based diastolic LCA flow agreed well (CCC/CV = 0.75/20.1%). Agreement between 4D flow MRI and 2D flow MRI was moderate for both diastolic VMAX and VPEAK (CCC/CV = 0.68/20.3% and 0.53/27.0%, respectively). In conclusion, the proposed framework of accelerated 4D flow MRI equipped with respiratory motion correction and compressed sensing image reconstruction enables repeatable diastolic LCA flow quantification that agrees well with 2D flow MRI.
format	article
author	Carmen P. S. Blanken Eric M. Schrauben Eva S. Peper Lukas M. Gottwald Bram F. Coolen Diederik F. van Wijk Jan J. Piek Gustav J. Strijkers R. Nils Planken Pim van Ooij Aart J. Nederveen
author_facet	Carmen P. S. Blanken Eric M. Schrauben Eva S. Peper Lukas M. Gottwald Bram F. Coolen Diederik F. van Wijk Jan J. Piek Gustav J. Strijkers R. Nils Planken Pim van Ooij Aart J. Nederveen
author_sort	Carmen P. S. Blanken
title	Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
title_short	Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
title_full	Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
title_fullStr	Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
title_full_unstemmed	Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction
title_sort	coronary flow assessment using accelerated 4d flow mri with respiratory motion correction
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e68d5c9679174e3fb1323c50b97e0049
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_version_	1718442669921796096

Coronary Flow Assessment Using Accelerated 4D Flow MRI With Respiratory Motion Correction

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