Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies

Insulinomas are considered rare indolent neuroendocrine neoplasms in human medicine, however when metastases occur no curative treatment is available thus, novel therapies are needed. Recently advances have been made in unraveling the pathophysiology of malignant insulinoma still major challenges hi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ylenia Capodanno, Barbara Altieri, Richard Elders, Annamaria Colao, Antongiulio Faggiano, Joerg Schrader
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Comparative oncology Malignant insulinoma Translational medicine Canine model Pancreatic neuroendocrine tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e68e51b74641445d9c1c86121b7dbe5c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e68e51b74641445d9c1c86121b7dbe5c
record_format	dspace
spelling	oai:doaj.org-article:e68e51b74641445d9c1c86121b7dbe5c2021-11-18T04:46:27ZCanine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies1936-523310.1016/j.tranon.2021.101269https://doaj.org/article/e68e51b74641445d9c1c86121b7dbe5c2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1936523321002606https://doaj.org/toc/1936-5233Insulinomas are considered rare indolent neuroendocrine neoplasms in human medicine, however when metastases occur no curative treatment is available thus, novel therapies are needed. Recently advances have been made in unraveling the pathophysiology of malignant insulinoma still major challenges hinder the development of a functional model to study them. Canine malignant insulinoma have similar recurrence and a poor prognosis as human malignant insulinoma. Additionally, both human and canine patients share extensively the same environment, tend to develop insulinoma seemingly spontaneously with an etiological role for hormones, at a similar incidence and stage of lifespan, with metastasis commonly to liver and regional lymph nodes, which are unresponsive to current therapies. However, the occurrence of metastases in dogs is as high as 95% compared with only 5–16% in human studies. From a comparative oncology perspective, the shared features with human insulinoma but higher incidence of metastasis in canine insulinoma suggests the latter as a model for human malignant insulinomas. With the common purpose of increasing survival rates of human and veterinary patients, in this review we are going to compare and analyze clinical, pathological and molecular aspects of canine and human insulinomas to evaluate the suitability of the canine model for future translational clinical studies.Ylenia CapodannoBarbara AltieriRichard EldersAnnamaria ColaoAntongiulio FaggianoJoerg SchraderElsevierarticleComparative oncologyMalignant insulinomaTranslational medicineCanine modelPancreatic neuroendocrine tumorNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101269- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Comparative oncology Malignant insulinoma Translational medicine Canine model Pancreatic neuroendocrine tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Comparative oncology Malignant insulinoma Translational medicine Canine model Pancreatic neuroendocrine tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ylenia Capodanno Barbara Altieri Richard Elders Annamaria Colao Antongiulio Faggiano Joerg Schrader Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies
description	Insulinomas are considered rare indolent neuroendocrine neoplasms in human medicine, however when metastases occur no curative treatment is available thus, novel therapies are needed. Recently advances have been made in unraveling the pathophysiology of malignant insulinoma still major challenges hinder the development of a functional model to study them. Canine malignant insulinoma have similar recurrence and a poor prognosis as human malignant insulinoma. Additionally, both human and canine patients share extensively the same environment, tend to develop insulinoma seemingly spontaneously with an etiological role for hormones, at a similar incidence and stage of lifespan, with metastasis commonly to liver and regional lymph nodes, which are unresponsive to current therapies. However, the occurrence of metastases in dogs is as high as 95% compared with only 5–16% in human studies. From a comparative oncology perspective, the shared features with human insulinoma but higher incidence of metastasis in canine insulinoma suggests the latter as a model for human malignant insulinomas. With the common purpose of increasing survival rates of human and veterinary patients, in this review we are going to compare and analyze clinical, pathological and molecular aspects of canine and human insulinomas to evaluate the suitability of the canine model for future translational clinical studies.
format	article
author	Ylenia Capodanno Barbara Altieri Richard Elders Annamaria Colao Antongiulio Faggiano Joerg Schrader
author_facet	Ylenia Capodanno Barbara Altieri Richard Elders Annamaria Colao Antongiulio Faggiano Joerg Schrader
author_sort	Ylenia Capodanno
title	Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies
title_short	Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies
title_full	Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies
title_fullStr	Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies
title_full_unstemmed	Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies
title_sort	canine insulinoma as a model for human malignant insulinoma research: novel perspectives for translational clinical studies
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/e68e51b74641445d9c1c86121b7dbe5c
work_keys_str_mv	AT yleniacapodanno canineinsulinomaasamodelforhumanmalignantinsulinomaresearchnovelperspectivesfortranslationalclinicalstudies AT barbaraaltieri canineinsulinomaasamodelforhumanmalignantinsulinomaresearchnovelperspectivesfortranslationalclinicalstudies AT richardelders canineinsulinomaasamodelforhumanmalignantinsulinomaresearchnovelperspectivesfortranslationalclinicalstudies AT annamariacolao canineinsulinomaasamodelforhumanmalignantinsulinomaresearchnovelperspectivesfortranslationalclinicalstudies AT antongiuliofaggiano canineinsulinomaasamodelforhumanmalignantinsulinomaresearchnovelperspectivesfortranslationalclinicalstudies AT joergschrader canineinsulinomaasamodelforhumanmalignantinsulinomaresearchnovelperspectivesfortranslationalclinicalstudies
_version_	1718425072254844928

Canine insulinoma as a model for human malignant insulinoma research: Novel perspectives for translational clinical studies

Ejemplares similares