Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival

Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may...

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Autores principales:	Rita Gemayel, Yudi Yang, Maria C. Dzialo, Jacek Kominek, Jakob Vowinckel, Veerle Saels, Leen Van Huffel, Elisa van der Zande, Markus Ralser, Jan Steensels, Karin Voordeckers, Kevin J. Verstrepen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e68fdad09bea48b29b4e7d92488ae766
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spelling	oai:doaj.org-article:e68fdad09bea48b29b4e7d92488ae7662021-12-02T15:38:38ZVariable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival10.1038/s41467-017-00533-42041-1723https://doaj.org/article/e68fdad09bea48b29b4e7d92488ae7662017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00533-4https://doaj.org/toc/2041-1723Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may tune the cell’s capacity to respond to sudden environmental perturbations.Rita GemayelYudi YangMaria C. DzialoJacek KominekJakob VowinckelVeerle SaelsLeen Van HuffelElisa van der ZandeMarkus RalserJan SteenselsKarin VoordeckersKevin J. VerstrepenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rita Gemayel Yudi Yang Maria C. Dzialo Jacek Kominek Jakob Vowinckel Veerle Saels Leen Van Huffel Elisa van der Zande Markus Ralser Jan Steensels Karin Voordeckers Kevin J. Verstrepen Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
description	Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may tune the cell’s capacity to respond to sudden environmental perturbations.
format	article
author	Rita Gemayel Yudi Yang Maria C. Dzialo Jacek Kominek Jakob Vowinckel Veerle Saels Leen Van Huffel Elisa van der Zande Markus Ralser Jan Steensels Karin Voordeckers Kevin J. Verstrepen
author_facet	Rita Gemayel Yudi Yang Maria C. Dzialo Jacek Kominek Jakob Vowinckel Veerle Saels Leen Van Huffel Elisa van der Zande Markus Ralser Jan Steensels Karin Voordeckers Kevin J. Verstrepen
author_sort	Rita Gemayel
title	Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
title_short	Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
title_full	Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
title_fullStr	Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
title_full_unstemmed	Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
title_sort	variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e68fdad09bea48b29b4e7d92488ae766
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Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival

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