Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival

Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may...

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Main Authors: Rita Gemayel, Yudi Yang, Maria C. Dzialo, Jacek Kominek, Jakob Vowinckel, Veerle Saels, Leen Van Huffel, Elisa van der Zande, Markus Ralser, Jan Steensels, Karin Voordeckers, Kevin J. Verstrepen
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/e68fdad09bea48b29b4e7d92488ae766
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