Circular RNAs in acute myeloid leukemia

Abstract Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inherent and acquired resistance to current therapies remains an unsolved clinical proble...

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Autores principales:	Vijendra Singh, Mohammed Hafiz Uddin, Jeffrey A. Zonder, Asfar S. Azmi, Suresh Kumar Balasubramanian
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Acute myeloid leukemia Non-coding RNA Circular RNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e69252ad152d4db9abeb3705116de2f9
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spelling	oai:doaj.org-article:e69252ad152d4db9abeb3705116de2f92021-11-21T12:02:26ZCircular RNAs in acute myeloid leukemia10.1186/s12943-021-01446-z1476-4598https://doaj.org/article/e69252ad152d4db9abeb3705116de2f92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12943-021-01446-zhttps://doaj.org/toc/1476-4598Abstract Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inherent and acquired resistance to current therapies remains an unsolved clinical problem. While current diagnostic modalities are primarily defined by gross morphology, cytogenetics, and to an extent, by deep targeted gene sequencing, there is an ongoing demand to identify newer diagnostic, therapeutic and prognostic biomarkers for AML. Recent interest in exploring the role of circular RNA (circRNA) in elucidating AML biology and therapy resistance has been promising. This review discerns the circular RNAs’ evolving role on the same scientific premise and attempts to identify its potential in managing AML.Vijendra SinghMohammed Hafiz UddinJeffrey A. ZonderAsfar S. AzmiSuresh Kumar BalasubramanianBMCarticleAcute myeloid leukemiaNon-coding RNACircular RNANeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Cancer, Vol 20, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute myeloid leukemia Non-coding RNA Circular RNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Acute myeloid leukemia Non-coding RNA Circular RNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Vijendra Singh Mohammed Hafiz Uddin Jeffrey A. Zonder Asfar S. Azmi Suresh Kumar Balasubramanian Circular RNAs in acute myeloid leukemia
description	Abstract Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inherent and acquired resistance to current therapies remains an unsolved clinical problem. While current diagnostic modalities are primarily defined by gross morphology, cytogenetics, and to an extent, by deep targeted gene sequencing, there is an ongoing demand to identify newer diagnostic, therapeutic and prognostic biomarkers for AML. Recent interest in exploring the role of circular RNA (circRNA) in elucidating AML biology and therapy resistance has been promising. This review discerns the circular RNAs’ evolving role on the same scientific premise and attempts to identify its potential in managing AML.
format	article
author	Vijendra Singh Mohammed Hafiz Uddin Jeffrey A. Zonder Asfar S. Azmi Suresh Kumar Balasubramanian
author_facet	Vijendra Singh Mohammed Hafiz Uddin Jeffrey A. Zonder Asfar S. Azmi Suresh Kumar Balasubramanian
author_sort	Vijendra Singh
title	Circular RNAs in acute myeloid leukemia
title_short	Circular RNAs in acute myeloid leukemia
title_full	Circular RNAs in acute myeloid leukemia
title_fullStr	Circular RNAs in acute myeloid leukemia
title_full_unstemmed	Circular RNAs in acute myeloid leukemia
title_sort	circular rnas in acute myeloid leukemia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e69252ad152d4db9abeb3705116de2f9
work_keys_str_mv	AT vijendrasingh circularrnasinacutemyeloidleukemia AT mohammedhafizuddin circularrnasinacutemyeloidleukemia AT jeffreyazonder circularrnasinacutemyeloidleukemia AT asfarsazmi circularrnasinacutemyeloidleukemia AT sureshkumarbalasubramanian circularrnasinacutemyeloidleukemia
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Circular RNAs in acute myeloid leukemia

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