Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents

Here, the authors identify potential drugs that target 3-chymotrypsin like protease (3CLpro), which is a pivotal protease for the replication of SARS-CoV-2. They found that off-target inhibitors such as ivermectin and micafungin inhibit 3CLpro enzyme activity, suggesting that these molecules could c...

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Autores principales:	Vicky Mody, Joanna Ho, Savannah Wills, Ahmed Mawri, Latasha Lawson, Maximilian C. C. J. C. Ebert, Guillaume M. Fortin, Srujana Rayalam, Shashidharamurthy Taval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e6979cbcb60044b5b4d28c086944625c
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spelling	oai:doaj.org-article:e6979cbcb60044b5b4d28c086944625c2021-12-02T10:49:10ZIdentification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents10.1038/s42003-020-01577-x2399-3642https://doaj.org/article/e6979cbcb60044b5b4d28c086944625c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01577-xhttps://doaj.org/toc/2399-3642Here, the authors identify potential drugs that target 3-chymotrypsin like protease (3CLpro), which is a pivotal protease for the replication of SARS-CoV-2. They found that off-target inhibitors such as ivermectin and micafungin inhibit 3CLpro enzyme activity, suggesting that these molecules could constitute useful therapies to inhibit SARS-CoV-2 replication.Vicky ModyJoanna HoSavannah WillsAhmed MawriLatasha LawsonMaximilian C. C. J. C. EbertGuillaume M. FortinSrujana RayalamShashidharamurthy TavalNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Vicky Mody Joanna Ho Savannah Wills Ahmed Mawri Latasha Lawson Maximilian C. C. J. C. Ebert Guillaume M. Fortin Srujana Rayalam Shashidharamurthy Taval Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
description	Here, the authors identify potential drugs that target 3-chymotrypsin like protease (3CLpro), which is a pivotal protease for the replication of SARS-CoV-2. They found that off-target inhibitors such as ivermectin and micafungin inhibit 3CLpro enzyme activity, suggesting that these molecules could constitute useful therapies to inhibit SARS-CoV-2 replication.
format	article
author	Vicky Mody Joanna Ho Savannah Wills Ahmed Mawri Latasha Lawson Maximilian C. C. J. C. Ebert Guillaume M. Fortin Srujana Rayalam Shashidharamurthy Taval
author_facet	Vicky Mody Joanna Ho Savannah Wills Ahmed Mawri Latasha Lawson Maximilian C. C. J. C. Ebert Guillaume M. Fortin Srujana Rayalam Shashidharamurthy Taval
author_sort	Vicky Mody
title	Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
title_short	Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
title_full	Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
title_fullStr	Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
title_full_unstemmed	Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
title_sort	identification of 3-chymotrypsin like protease (3clpro) inhibitors as potential anti-sars-cov-2 agents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6979cbcb60044b5b4d28c086944625c
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Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents

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